Document Detail

Time course of blood pressure changes after intravenous administration of propranolol or furosemide in hypertensive patients.
MedLine Citation:
PMID:  6195464     Owner:  NLM     Status:  MEDLINE    
The time course of changes in supine and standing blood pressures, heart rate, plasma renin activity, and plasma noradrenaline concentration after intravenous administration of propranolol (0.20 mg . kg-1, with a maximum of 15 mg) or furosemide (40 mg) was studied for a period of 8 h in hypertensive patients. Twenty minutes after intravenous injection of propranolol or furosemide, supine blood pressure was unchanged. Thereafter, blood pressure started to decrease gradually. Maximum reduction was obtained after 4-5 h. Twenty minutes after administration of propranolol, heart rate and plasma renin activity were reduced, and remained so during the following 8 h. Supine plasma noradrenaline concentration did not change significantly after propranolol, but standing levels, showed a tendency to increase as blood pressure fell. Twenty minutes after administration of furosemide, plasma renin activity was increased and remained elevated during the following 8 h. Heart rate and plasma noradrenaline concentration were unchanged after 20 min, but both increased gradually as blood pressure started to fall. The results show that intravenous administration of both propranolol and furosemide leads to a delayed reduction of blood pressure. The increase in total peripheral resistance, which prevents blood pressure from falling acutely after intravenous injection of propranolol, is not reflected in an acute rise in plasma noradrenaline. The delayed hypotensive response does not seem to be due to a return of sympathetic activity to pretreatment levels, since plasma noradrenaline concentration shows a tendency to rise as blood pressure falls.
M E van Hooff; R J Does; K H Rahn; M A van Baak
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  5     ISSN:  0160-2446     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:    1983 Sep-Oct
Date Detail:
Created Date:  1983-12-20     Completed Date:  1983-12-20     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  773-7     Citation Subset:  IM    
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MeSH Terms
Blood Pressure / drug effects*
Furosemide / administration & dosage,  pharmacology*
Hypertension / drug therapy,  physiopathology*
Injections, Intravenous
Middle Aged
Norepinephrine / blood
Propranolol / administration & dosage,  pharmacology*
Reg. No./Substance:
51-41-2/Norepinephrine; 525-66-6/Propranolol; 54-31-9/Furosemide

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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