Document Detail


Time course of antibody response to tetanus toxoid and pneumococcal capsular polysaccharides in patients infected with HIV.
MedLine Citation:
PMID:  9859960     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The temporal course of the humoral immune response to T-cell-dependent and T-cell-independent type 2 antigens was evaluated in HIV-infected patients. In all, 26 seropositive patients were vaccinated with tetanus toxoid and 23-valent pneumococcal vaccines; total IgG and IgG1 antibodies to tetanus toxoid (Ttox) and total IgG and IgG2 antibodies against 23 Streptococcus pneumoniae capsular antigens (PPS) were measured at baseline, 2 months, and 12 months after vaccination. For the Ttox, baseline levels of IgG1 (Ttox-IgG1) increased from 11.0 to 19.5 mg/L at 2 months postimmunization. Overall only 6 patients (23%) showed a significant response. At 12 months postvaccination, Ttox-IgG and T-tox-IgG1 were significantly lower than baseline levels (Ttox IgG basal; 11.0 mg/L, 12 months; 0.8 mg/L, Ttox IgG1 baseline; 13.1 mg/L, Ttox IgG1 12 months; 2.4 mg/L) and in 10 patients, antibodies that fell below protective levels (0.6 mg/L). In contrast with PPS, a significant response was observed at 2 and 12 months (PPS-IgG basal; 35.9 U/ml, 2 months; 151.4 U/ml, 12 months; 59.7 U/ml; PPS-IgG2 baseline 20.3 U/ml, 2 months; 113.2 U/ml, 12 months; 51.9 U/ml). Overall, 19 patients (76%) showed an immune response to pneumococcal polysaccharides antigens. Immunization with the Ttox T-cell-dependent antigen fails to elicit a significant immune response and may induce inhibition of antibody production in HIV-infected patients. In contrast, immunization with a T-cell-independent type 2 antigen can cause the pneumococcal polysaccharides to induce significant immune response in a high proportion of HIV-infected patients.
The temporal course of the humoral response to T-cell-dependent and T-cell-independent type 2 antigens was evaluated in HIV-infected patients. 26 HIV-seropositive patients were vaccinated with tetanus toxoid and 23-valent pneumococcal vaccines; total IgG and IgG1 antibodies to tetanus toxoid (Ttox) and total IgG and IgG2 antibodies against 23 Streptococcus pneumoniae capsular antigens (PPS) were measured at baseline, 2 months, and 12 months after vaccination. For the Ttox, baseline levels of IgG1 (Ttox-IgG1) increased from 11.0 to 19.5 mg/L at 2 months postimmunization. Overall, 6 patients (23%) showed a significant response. At 12 months postvaccination, Ttox-IgG and Ttox-IgG1 were significantly lower than baseline levels, and in 10 patients, antibodies fell below protective levels. In contrast with PPS, a significant response was observed at 2 and 12 months. Overall, 19 patients (76%) showed an immune response to pneumococcal polysaccharide antigens. Immunization with the Ttox T-cell-dependent antigen elicits no significant immune response and may induce inhibition of antibody production in HIV-infected patients. In contrast, immunization with a T-cell-independent type 2 antigen can cause the pneumococcal polysaccharides to induce significant immune response in a high proportion of HIV-infected patients.
Authors:
E Talesnik; P A Vial; J Labarca; C Méndez; X Soza
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of acquired immune deficiency syndromes and human retrovirology : official publication of the International Retrovirology Association     Volume:  19     ISSN:  1077-9450     ISO Abbreviation:  J. Acquir. Immune Defic. Syndr. Hum. Retrovirol.     Publication Date:  1998 Dec 
Date Detail:
Created Date:  1998-12-31     Completed Date:  1998-12-31     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9501482     Medline TA:  J Acquir Immune Defic Syndr Hum Retrovirol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  471-7     Citation Subset:  IM; J; X    
Affiliation:
Department of Pediatrics, Facultad de Medicina, Pontificia Universidad Católica de Chile, Santiago. reumatomed.puc.cl.
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MeSH Terms
Descriptor/Qualifier:
Adult
Antibodies, Bacterial / biosynthesis*,  blood
Antibody Specificity
Bacterial Vaccines / immunology*
Cohort Studies
Enzyme-Linked Immunosorbent Assay
Female
Follow-Up Studies
HIV Infections / immunology*
Humans
Immunoglobulin G / biosynthesis,  blood
Male
Pneumococcal Vaccines
Streptococcus pneumoniae / immunology*
Tetanus Toxoid / immunology*
Time Factors
Chemical
Reg. No./Substance:
0/Antibodies, Bacterial; 0/Bacterial Vaccines; 0/Immunoglobulin G; 0/Pneumococcal Vaccines; 0/Tetanus Toxoid

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