Document Detail

Time course alteration of endothelin-1 gene expression in the heart during exercise and recovery from post-exercise periods in rats.
MedLine Citation:
PMID:  15838345     Owner:  NLM     Status:  MEDLINE    
Endothelin-1 (ET-1) is produced by endothelial cells and cardiac myocytes. ET-1 has potent positive inotropic and chronotropic effects in the heart and causes myocardial cell hypertrophy. We investigated the alteration of gene expression of ET-1 in the heart of rats during acute exercise and 24 hour postexercise periods. Sprague-Dawley rats performed treadmill running for 30 minutes at a speed of 30 m/minute. We determined the expression of preproendothelin-1 mRNA in the rat hearts of resting (control) and 0, 0.5, 1, 3, 6, 12, and 24 hour post-exercise time points, respectively. The percent changes in expression of preproendothelin-1 mRNA in the heart from resting control rats were significantly increased at the time point of 1 hour post-exercise (199.0 +/- 33.6%, P < 0.05), and this enhancement returned to the level of resting control rats at the time points of 6, 12, and 24 hours post-exercise. These results suggest that a bout of exercise causes time-related enhancement of gene expression of ET-1 in the rat hearts during acute exercise and 24 hour post-exercise periods. Therefore, an exercise-induced change of ET-1 gene expression in the heart may participate in mechanisms of exercise-induced and/or training-induced adaptive responses of the heart.
Motoyuki Iemitsu; Takashi Miyauchi; Seiji Maeda; Mitsuo Matsuda; Katsutoshi Goto; Iwao Yamaguchi
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of cardiovascular pharmacology     Volume:  44 Suppl 1     ISSN:  1533-4023     ISO Abbreviation:  J. Cardiovasc. Pharmacol.     Publication Date:  2004 Nov 
Date Detail:
Created Date:  2005-04-19     Completed Date:  2008-11-03     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  7902492     Medline TA:  J Cardiovasc Pharmacol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  S447-50     Citation Subset:  IM    
Center for Tsukuba Advanced Research Alliance, University of Tsukuba, Tsukuba, Ibaraki, Japan.
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MeSH Terms
Endothelin-1 / genetics,  metabolism*
Myocardium / metabolism*
Physical Exertion*
Protein Precursors / genetics,  metabolism*
RNA, Messenger / metabolism
Rats, Sprague-Dawley
Recovery of Function
Time Factors
Reg. No./Substance:
0/Endothelin-1; 0/Protein Precursors; 0/RNA, Messenger

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