Document Detail

Time- and concentration-dependent inhibition of the clonogenic growth of N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide-induced murine bladder tumor cell lines by cis-diamminedichloroplatinum(II).
MedLine Citation:
PMID:  7199379     Owner:  NLM     Status:  MEDLINE    
The influence of the concentration and time of exposure to cis-diamminedichloroplatinum on the inhibition of the clonogenic growth of three N-[4-(5-nitro-2-furyl)-2-thiazolyl]formamide mouse bladder tumor cell lines was evaluated in a tumor colony assay. Drug testing was performed in the murine model, and tumor cells were removed from the animals for in vitro testing. Murine drug testing revealed marked cis-diamminedichloroplatinum sensitivity of all three mouse bladder tumor lines. One-hr incubation in cis-diamminedichloroplatinum was an adequate time of drug exposure to produce in vitro colony survival curves predictive of in vivo sensitivity to the drug. Furthermore, it was found that 6- to greater than 24-hr exposure to the drug was required to produce colony survival curves in the tumor colony assay predictive of tumor sensitivity. High drug concentrations using 1-hr drug incubation or continuous incubation in drug both produced colony survival curves predictive of tumor sensitivity. Both methods, however, would require higher products of the drug concentration multiplied by time curves than could theoretically be clinically achievable in the murine model. Until pharmacokinetic data on cis-diamminedichloroplatinum are available in this murine model, higher drug sensitivity boundaries than are presently being used for other chemotherapeutic agents will have to be utilized when testing these mouse bladder tumor cell lines for their sensitivity to cis-diamminedichloroplatinum in a tumor colony assay.
H B Niell; C A Wood; D D Mickey; M S Soloway
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Cancer research     Volume:  42     ISSN:  0008-5472     ISO Abbreviation:  Cancer Res.     Publication Date:  1982 Mar 
Date Detail:
Created Date:  1982-05-12     Completed Date:  1982-05-12     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  2984705R     Medline TA:  Cancer Res     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  807-11     Citation Subset:  IM    
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MeSH Terms
Cell Line
Cell Survival
Cisplatin / pharmacology*
Dose-Response Relationship, Drug
Drug Evaluation, Preclinical / methods
Mice, Inbred C3H
Neoplasm Transplantation
Time Factors
Urinary Bladder Neoplasms / chemically induced*,  pathology
Reg. No./Substance:
0/Thiazoles; 15663-27-1/Cisplatin; 24554-26-5/FANFT

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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