Document Detail

Time components of circulatory transport from the lungs to a peripheral artery in humans.
MedLine Citation:
PMID:  16485105     Owner:  NLM     Status:  MEDLINE    
Blood gas changes occurring in the lung undergo delay and damping on their way to a peripheral artery sampling site. Knowledge of the time components of circulatory transfer is important for the understanding of respiratory control and cardiovascular reflexes in response to blood gas transients. Providing steady state with regard to VA/Q distribution, cardiac output and peripheral blood flow, the relationship between the time courses of small end-tidal and peripheral PO2 changes is determined by the transfer function of the interposed vascular segment. This transfer function, expressed as delay time TD and mean transit time (MTT), was measured in six well-trained subjects, allowing the calculation of arterial time-courses from end-tidal to the reverse. They were studied at rest and during four different dynamic leg exercise intensities in the supine posture. TD and MTT amounted to 15.8 +/- 1.7 (mean +/- SEM) and 18.3 +/- 2.1 s at rest and were shortened to 7.7 +/- 0.6 and 11.5 +/- 1.8 s during exercise at 170 W. The shortening of TD and MTT did not appear to be simply an inverse function of cardiac output, suggesting that the shortening occurs in the central circulatory segment but not in the arm segment.
P Lindholm; L Karlsson; H Gill; O Wigertz; D Linnarsson
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2006-02-17
Journal Detail:
Title:  European journal of applied physiology     Volume:  97     ISSN:  1439-6319     ISO Abbreviation:  Eur. J. Appl. Physiol.     Publication Date:  2006 May 
Date Detail:
Created Date:  2006-04-21     Completed Date:  2006-07-17     Revised Date:  2008-11-21    
Medline Journal Info:
Nlm Unique ID:  100954790     Medline TA:  Eur J Appl Physiol     Country:  Germany    
Other Details:
Languages:  eng     Pagination:  96-102     Citation Subset:  IM    
Department of Physiology and Pharmacology, Section of Environmental Physiology, Karolinska Institutet, 17177, Stockholm, Sweden.
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MeSH Terms
Arteries / physiology*
Biological Transport, Active
Computer Simulation
Leg / blood supply,  physiology*
Lung / blood supply*,  physiology*
Models, Biological
Oxygen / blood*
Physical Exertion / physiology*
Pulmonary Gas Exchange / physiology*
Time Factors
Reg. No./Substance:

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