Document Detail

Time averaging and fitting of nonlinear metabolic changes: the issue of the time index choice applied to 31P MRS investigation of muscle energetics.
MedLine Citation:
PMID:  11273744     Owner:  NLM     Status:  MEDLINE    
We present an exact analytical method dedicated to fitting time-dependent exponential-like changes in MR spectra. As an illustration, this method has been applied to fitting metabolic changes recorded by 31P MRS in human skeletal muscle occurring during a rest-exercise-recovery protocol. When recording metabolic changes with the accumulative method, the time averaging of the MR signals implies the choice of a time index for fitting any changes in the features of the associated MR spectra. A critical examination of the different ways (constant, linear, and exponential) of choosing the time index is reported. By numerical analysis, we have calculated the errors generated by the three methods and we have compared their sensitivity to noise. In the case of skeletal muscle, both constant and linear methods introduce large and uncontrolled errors for the whole set of metabolic parameters derived from [PCr] changes. In contrast, the exponential method affords a reliable estimation of critical parameters in muscle bioenergetics in both normal and pathological situations. This method is very easy to implement and provides an exact analytical solution to fitting changes in MR spectra recorded by the accumulative method.
G Simond; D Bendahan; P J Cozzone
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of magnetic resonance (San Diego, Calif. : 1997)     Volume:  149     ISSN:  1090-7807     ISO Abbreviation:  J. Magn. Reson.     Publication Date:  2001 Mar 
Date Detail:
Created Date:  2001-03-29     Completed Date:  2001-07-26     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  9707935     Medline TA:  J Magn Reson     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1-7     Citation Subset:  IM    
Copyright Information:
Copyright 2001 Academic Press.
Centre de Résonance Magnétique Biologique et Médicale (CRMBM), UMR CNRS 6612, Faculté de Médecine de Marseille, 27 boulevard Jean Moulin, Marseille, 13005, France.
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MeSH Terms
Computer Simulation
Energy Metabolism / physiology*
Exercise / physiology*
Magnetic Resonance Spectroscopy*
Mathematical Computing
Muscle, Skeletal / physiology*
Phosphocreatine / metabolism*
Reg. No./Substance:

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