| Time-averaged concentration of dialysate sodium relates with sodium load and interdialytic weight gain during sodium-profiling hemodialysis. | |
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MedLine Citation:
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PMID: 12148101 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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BACKGROUND: Factors determining sodium level during sodium-profiling hemodialysis rarely have been studied. We hypothesized that the time-averaged concentration of dialysate sodium (TAC(Na)) is related to intradialytic sodium load and interdialytic complications. METHODS: Eleven patients underwent 6-week periods of (1) conventional hemodialysis with a dialysate sodium concentration of 138 mmol/L (TAC(138)) and (2) sodium-profiling hemodialysis with a dialysate sodium concentration of 150 to 138 mmol/L (TAC(Na), 140 mmol/L [TAC(140)]) and (3) 155 to 130 mmol/L (TAC(Na), 147 mmol/L [TAC(147)]). Serum sodium level, weight gain, 24-hour blood pressure, and intradialytic and interdialytic discomfort were compared. RESULTS: Serum sodium levels increased during the TAC(140) and TAC(147) periods (P < 0.05 compared with predialysis serum sodium). Intradialytic change in sodium level correlated positively with TAC(Na) (r = 0.945; P < 0.001). Regression analysis indicates that positive sodium load occurred with TAC(Na) more than 137.8 mmol/L. Interdialytic weight gain increased in proportion to TAC(Na) (P < 0.05 compared with each other period), with a positive correlation (r = 0.823; P < 0.001). TAC(Na) causing interdialytic weight gain less than 3 kg was estimated to be less than 143.5 mmol/L. Intradialytic hypotension decreased, but interdialytic discomforts increased during the TAC(147) period (P < 0.05 compared with TAC(138) and TAC(140)). Mean 24-hour blood pressures and pressure loads increased during the TAC(147) period (P < 0.05 compared with TAC(138) and TAC(140)). Mean diastolic blood pressure correlated positively with TAC(Na) (r = 0.354; P < 0.05). CONCLUSION: TAC(Na) is a factor determining sodium load and interdialytic complications during sodium-profiling hemodialysis. Defining the optimal TAC(Na) for individual centers based on their protocols will be helpful to avoid sodium load and excessive weight gain. |
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Authors:
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Joon Ho Song; Seoung Woo Lee; Chang-Kook Suh; Moon-Jae Kim |
Publication Detail:
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Type: Clinical Trial; Comparative Study; Journal Article; Randomized Controlled Trial |
Journal Detail:
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Title: American journal of kidney diseases : the official journal of the National Kidney Foundation Volume: 40 ISSN: 1523-6838 ISO Abbreviation: Am. J. Kidney Dis. Publication Date: 2002 Aug |
Date Detail:
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Created Date: 2002-07-30 Completed Date: 2002-08-12 Revised Date: 2006-11-15 |
Medline Journal Info:
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Nlm Unique ID: 8110075 Medline TA: Am J Kidney Dis Country: United States |
Other Details:
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Languages: eng Pagination: 291-301 Citation Subset: IM |
Copyright Information:
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Copyright 2002 by the National Kidney Foundation, Inc. |
Affiliation:
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Department of Internal Medicine, Inha University College of Medicine, Inchon City, Korea. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Blood Pressure
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drug effects,
physiology Dialysis Solutions / administration & dosage, metabolism* Female Humans Hypertension / etiology Male Middle Aged Renal Dialysis / adverse effects, methods* Sodium / administration & dosage*, adverse effects, blood, metabolism* Time Factors Weight Gain / drug effects, physiology* |
| Chemical | |
Reg. No./Substance:
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0/Dialysis Solutions; 7440-23-5/Sodium |
| Comments/Corrections | |
Erratum In:
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Am J Kidney Dis 2002 Dec;40(6):1357 |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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