Document Detail

A time trend study of significantly elevated perfluorocarboxylate levels in humans after using fluorinated ski wax.
MedLine Citation:
PMID:  20158198     Owner:  NLM     Status:  In-Data-Review    
A time trend study focusing on ski waxing technicians' exposure to perfluorinated chemicals (PFCs) from fluorinated wax fumes was performed in 2007/2008. Levels of eight perfluorocarboxylates and three perfluorosulfonates were analyzed in monthly blood samples from eight technicians. Samples were collected before the ski season, i.e., preseason, then at four FIS World Cup competitions in cross country skiing, and finally during an unexposed 5-month postseason period. The perfluorinated carboxylates perfluoroheptanoic acid (PFHpA), perfluorooctanoic acid (PFOA), perfluorononanoic acid (PFNA), perfluorodecanoic acid (PFDA), and perfluoroundecanoic acid (PFUnDA) bioaccumulate, and continued exposure may contribute to elevated levels in ski technicians compared to the general population. The wax technicians' median blood level of PFOA is 112 ng/mL compared to 2.5 ng/mL in the general Swedish population. A significant correlation was found between number of working years and levels of perfluorocarboxylates. The PFOA levels in three technicians with "low" initial levels of PFOA (<10.0 ng/mL in preseason blood) increased by 254, 134, and 120%, whereas five technicians with "high" initial levels (>100 ng/mL in preseason sample) were at steady state. PFHxA is suggested to have a short half-life in humans relative the other perfluorocarboxylates. The levels of perfluorosulfonates were unaffected by the wax exposure.
Helena Nilsson; Anna Kärrman; Håkan Westberg; Anna Rotander; Bert van Bavel; Gunilla Lindström
Related Documents :
3088678 - Metabolism of viprostol--a synthetic vasodilator pge2 analog.
10569178 - Use of dipyridyl-dithio substrates to measure directly the protein disulfide-thiol inte...
23846548 - How reliable is the hard-soft acid-base principle? an assessment from numerical simulat...
12575908 - Casein and whey exert different effects on plasma amino acid profiles, gastrointestinal...
19744768 - Long-term evaluation of coal fly ash and mine tailings co-placement: a site-specific st...
20524818 - Interaction of ascorbic acid and tocopherol on beta-carotene modulated carcinogenesis.
Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Environmental science & technology     Volume:  44     ISSN:  0013-936X     ISO Abbreviation:  Environ. Sci. Technol.     Publication Date:  2010 Mar 
Date Detail:
Created Date:  2010-03-11     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0213155     Medline TA:  Environ Sci Technol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2150-5     Citation Subset:  IM    
Man-Technology-Environment (MTM) Research Centre, Orebro University, SE-701 82 Orebro, Sweden.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  How are Centrosymmetric and Noncentrosymmetric Structures Achieved in Uranyl Borates?
Next Document:  Role of Continuous Phase Anionic Polysaccharides on the Oxidative Stability of Menhaden Oil-in-Water...