Document Detail


Time-Restricted Feeding Is a Preventative and Therapeutic Intervention against Diverse Nutritional Challenges.
MedLine Citation:
PMID:  25470547     Owner:  NLM     Status:  In-Data-Review    
Abstract/OtherAbstract:
Because current therapeutics for obesity are limited and only offer modest improvements, novel interventions are needed. Preventing obesity with time-restricted feeding (TRF; 8-9 hr food access in the active phase) is promising, yet its therapeutic applicability against preexisting obesity, diverse dietary conditions, and less stringent eating patterns is unknown. Here we tested TRF in mice under diverse nutritional challenges. We show that TRF attenuated metabolic diseases arising from a variety of obesogenic diets, and that benefits were proportional to the fasting duration. Furthermore, protective effects were maintained even when TRF was temporarily interrupted by ad libitum access to food during weekends, a regimen particularly relevant to human lifestyle. Finally, TRF stabilized and reversed the progression of metabolic diseases in mice with preexisting obesity and type II diabetes. We establish clinically relevant parameters of TRF for preventing and treating obesity and metabolic disorders, including type II diabetes, hepatic steatosis, and hypercholesterolemia.
Authors:
Amandine Chaix; Amir Zarrinpar; Phuong Miu; Satchidananda Panda
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Cell metabolism     Volume:  20     ISSN:  1932-7420     ISO Abbreviation:  Cell Metab.     Publication Date:  2014 Dec 
Date Detail:
Created Date:  2014-12-04     Completed Date:  -     Revised Date:  2014-12-06    
Medline Journal Info:
Nlm Unique ID:  101233170     Medline TA:  Cell Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  991-1005     Citation Subset:  IM    
Copyright Information:
Copyright © 2014 Elsevier Inc. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Grant Support
ID/Acronym/Agency:
P30 CA014195/CA/NCI NIH HHS; P30 EY019005/EY/NEI NIH HHS; P50 GM085764/GM/NIGMS NIH HHS; R01 DK091618/DK/NIDDK NIH HHS; R01 EY016807/EY/NEI NIH HHS; R24 DK080506/DK/NIDDK NIH HHS; S10 RR027450/RR/NCRR NIH HHS; T32 DK007202/DK/NIDDK NIH HHS

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