| Time for initial response to steroids is a major prognostic factor in idiopathic nephrotic syndrome. | |
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MedLine Citation:
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PMID: 20223477 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To identify early prognostic factors for idiopathic nephrotic syndrome (INS) in childhood. STUDY DESIGN: A retrospective analysis of 103 patients with INS at onset, all treated in a single center with the same induction protocol, was conducted. Minimum length of follow-up was 2 years; median length of follow-up was 43 months. Survival data were assessed with Cox-Mantel analysis. Predictive values were estimated with receiver operating characteristic curves. RESULTS: The median time of response to steroid therapy was 7 days. A significant association was found between the interval from onset of steroid therapy to remission and the risk of relapsing within 3 months after steroid therapy discontinuation (P < .0001). A similar association was found between the time to achieve remission and the risk of developing frequent relapsing or steroid-dependent nephrotic syndrome (P < .0001), the prescription of maintenance steroid therapy (P < .003), and the prescription of all other non-steroid drugs (P < .0001) during follow-up. Patients with non-relapsing and infrequent relapsing nephrotic syndrome had a median time to achieve remission <7 days; in patients with frequent relapsing and steroid-dependent nephrotic syndrome, this median was >7 days. CONCLUSION: The interval from onset of steroid therapy to remission is an accurate early prognostic factor in INS. |
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Authors:
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Marina Vivarelli; Eleonora Moscaritolo; Aggelos Tsalkidis; Laura Massella; Francesco Emma |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-03-10 |
Journal Detail:
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Title: The Journal of pediatrics Volume: 156 ISSN: 1097-6833 ISO Abbreviation: J. Pediatr. Publication Date: 2010 Jun |
Date Detail:
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Created Date: 2010-05-24 Completed Date: 2010-06-17 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375410 Medline TA: J Pediatr Country: United States |
Other Details:
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Languages: eng Pagination: 965-71 Citation Subset: AIM; IM |
Copyright Information:
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Copyright 2010 Mosby, Inc. All rights reserved. |
Affiliation:
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Division of Nephrology and Dialysis, Bambino Ges? Children's Hospital and Research Institute, Rome, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cyclosporine
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therapeutic use Female Glucocorticoids / therapeutic use* Humans Immunosuppressive Agents / therapeutic use Male Nephrotic Syndrome / drug therapy* Prednisone / therapeutic use* Prognosis ROC Curve Remission Induction Retrospective Studies Sensitivity and Specificity |
| Chemical | |
Reg. No./Substance:
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0/Glucocorticoids; 0/Immunosuppressive Agents; 53-03-2/Prednisone; 59865-13-3/Cyclosporine |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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