| Time dependent bladder apoptosis induced by acute bladder outlet obstruction and subsequent emptying is associated with decreased MnSOD expression and Bcl-2/Bax ratio. | |
| | |
MedLine Citation:
|
PMID: 21060756 Owner: NLM Status: In-Process |
Abstract/OtherAbstract:
|
Ischemia/reperfusion (I/R) injury-induced oxidative stress plays an important role in the functional impairment of the bladder following acute bladder outlet obstruction (BOO) via induction of apoptosis. The purpose of this study was to investigate the time course of the bladder apoptosis, and apoptosis related molecular changes in the early stage of acute BOO. Twelve-week-old male Sprague Dawley rats were divided into control, acute BOO only (I), and acute BOO plus subsequent emptying (I/R) for 30, 60, 120 min, 3 days and 2 weeks. We examined the extent of bladder apoptosis, expression of Mn-superoxide dismutase (Mn-SOD), Bcl-2, Bax, caspase 3 and poly (ADP-ribose) (PAR) in the bladder. Bladder apoptosis was significantly increased in the I/R group at 30, 60, and 120 min following bladder emptying. BOO plus subsequent emptying for 30, 60, 120 min showed significant decrease in MnSOD and Bcl-2 expression, and significant increase in caspase 3, Bax expression, and amounts of PAR. These results indicate that bladder apoptosis, induced by acute BOO and subsequent emptying, is associated with decreased MnSOD expression, increased PARP activity and imbalance in apoptosis pathways. |
| | |
Authors:
|
Wen Ji Li; Mi-Kyung Shin; Seung-June Oh |
Related Documents
:
|
10200466 - The adenomatous polyposis coli protein and retinoblastoma protein are cleaved early in ... 10882796 - Involvement of caspase 3-like protease in methylmercury-induced apoptosis of primary cu... 12893746 - Cathepsin-b-dependent apoptosis triggered by antithymocyte globulins: a novel mechanism... 11857026 - Characterization of cell death induced by vinflunine, the most recent vinca alkaloid in... 16988446 - In vitro assay of immunostimulatory activities of plasmid vectors. 16350546 - Asthma induced by isocyanates: a model of ige-independent asthma. |
Publication Detail:
|
Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2010-10-26 |
Journal Detail:
|
Title: Journal of Korean medical science Volume: 25 ISSN: 1598-6357 ISO Abbreviation: J. Korean Med. Sci. Publication Date: 2010 Nov |
Date Detail:
|
Created Date: 2010-11-09 Completed Date: - Revised Date: - |
Medline Journal Info:
|
Nlm Unique ID: 8703518 Medline TA: J Korean Med Sci Country: Korea (South) |
Other Details:
|
Languages: eng Pagination: 1652-6 Citation Subset: IM |
Affiliation:
|
Department of Urology, Seoul National University Hospital, and Neuroscience Research Institute, Medical Research Center, Seoul National University, Seoul, Korea. |
Export Citation:
|
APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
|
|
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
Previous Document: The expression of corticotropin-releasing factor in the central nucleus of the amygdala, induced by ...
Next Document: Determination of an applicable FRAX model in Korean women.