Document Detail


Time-Course Study of Different Innate Immune Mediators Produced by Ultraviolet-Irradiated Skin. Comparative Effects of Short and Daily versus a Single Harmful UV Exposure.
MedLine Citation:
PMID:  25438991     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
The modulatory effects of solar ultraviolet radiation (UVR) on the immune system have been widely studied. As the skin is the main target of UVR, our purpose was to compare the impact of two contrasting ways to be exposed to sunlight on the skin innate immunity. Hairless mice were UV irradiated with a single high UV dose (shUVd) simulating a harmful exposure, or with repetitive low UV doses (rlUVd) simulating short occasional daily exposures. Skin samples were taken at different times post-UV irradiation to evaluate skin histology, inflammatory cell recruitment, epidermal T cell population and the mitochondrial function of epidermal cells. The transcriptional profiles of pro-inflammatory cytokines, chemokines, antimicrobial peptides and TLRs were evaluated by RT-PCR and ELISA in tissue homogenates. Finally, a lymphangiography was performed to assess modification in the lymphatic vessel system. A shUVd produces a deep inflammatory state characterized by the production of pro-inflammatory cytokines and chemokines that, in turn, induces the recruitment of neutrophils and macrophages into the irradiated area. On the other hand, rlUVd drive the skin to a photo-induced alert state in which there is no sign of inflammation, but the epithelium undergoes changes in thickness, the lymphatic circulation increases, and the transcription of antimicrobial peptides is induced. This article is protected by copyright. All rights reserved.
Authors:
E M Cela; A Friedrich; M L Paz; S I Vanzulli; J Leoni; D H González Maglio
Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2014-11-28
Journal Detail:
Title:  Immunology     Volume:  -     ISSN:  1365-2567     ISO Abbreviation:  Immunology     Publication Date:  2014 Nov 
Date Detail:
Created Date:  2014-12-2     Completed Date:  -     Revised Date:  2014-12-3    
Medline Journal Info:
Nlm Unique ID:  0374672     Medline TA:  Immunology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
This article is protected by copyright. All rights reserved.
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