Document Detail


Award article: Microcirculatory Society Award for Excellence in Lymphatic Research: time course of myocardial interstitial edema resolution and associated left ventricular dysfunction.
MedLine Citation:
PMID:  22708850     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
OBJECTIVE: Although the causal relationship between acute myocardial edema and cardiac dysfunction has been established, resolution of myocardial edema and subsequent recovery of cardiac function have not been established. The time to resolve myocardial edema and the degree that cardiac function is depressed after edema resolves are not known. We therefore characterized temporal changes in cardiac function as acute myocardial edema formed and resolved.
METHODS: Acute myocardial edema was induced in the canine model by elevating coronary sinus pressure for three hours. Myocardial water content and cardiac function were determined before and during coronary sinus pressure elevation, and after coronary sinus pressure restoration.
RESULTS: Although no change in systolic properties was detected, accumulation of water in myocardial interstitium was associated with increased diastolic stiffness. When coronary sinus pressure was relieved, myocardial edema resolved within 180 minutes. Diastolic stiffness, however, remained significantly elevated compared with baseline values, and cardiac function remained compromised.
CONCLUSIONS: The present work suggests that the cardiac dysfunction caused by the formation of myocardial edema may persist after myocardial edema resolves. With the advent of new imaging techniques to quantify myocardial edema, this insight provides a new avenue for research to detect and treat a significant cause of cardiac dysfunction.
Authors:
Ranjeet M Dongaonkar; Randolph H Stewart; Christopher M Quick; Karen L Uray; Charles S Cox; Glen A Laine
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural    
Journal Detail:
Title:  Microcirculation (New York, N.Y. : 1994)     Volume:  19     ISSN:  1549-8719     ISO Abbreviation:  Microcirculation     Publication Date:  2012 Nov 
Date Detail:
Created Date:  2012-11-20     Completed Date:  2013-05-03     Revised Date:  2013-11-06    
Medline Journal Info:
Nlm Unique ID:  9434935     Medline TA:  Microcirculation     Country:  United States    
Other Details:
Languages:  eng     Pagination:  714-22     Citation Subset:  IM    
Copyright Information:
© 2012 John Wiley & Sons Ltd.
Affiliation:
Michael E DeBakey Institute, Texas A&M University, College Station, Texas 77843-4466, USA.
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MeSH Terms
Descriptor/Qualifier:
Animals
Awards and Prizes
Blood Pressure*
Coronary Sinus / metabolism*,  pathology
Dogs
Edema
Myocardium / metabolism*,  pathology
Time Factors
Ventricular Dysfunction, Left / metabolism*,  pathology,  physiopathology
Water / metabolism*
Grant Support
ID/Acronym/Agency:
HL092916/HL/NHLBI NIH HHS; HL36115/HL/NHLBI NIH HHS; R01 HL092916/HL/NHLBI NIH HHS
Chemical
Reg. No./Substance:
7732-18-5/Water
Comments/Corrections

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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