Document Detail

Time course and mechanisms of endo-epicardial electrical dissociation during atrial fibrillation in the goat.
MedLine Citation:
PMID:  20978006     Owner:  NLM     Status:  In-Data-Review    
AIMS: This study aims to determine the degree and mechanisms of endo-epicardial dissociation of electrical activity during atrial fibrillation (AF) and endo-epicardial differences in atrial electrophysiology at different stages of atrial remodelling.
METHODS AND RESULTS: Simultaneous high-density endo-epicardial mapping of AF was performed on left atrial free walls of goats with acute AF, after 3 weeks, and after 6 months of AF (all n = 7). Endo-epicardial activation time differences and differences in the direction of conduction vectors were calculated, endocardial and epicardial effective refractory periods (ERP) were determined, and fractionation of electrograms was quantified. Histograms of endo-epicardial activation time differences and differences in the direction of conduction vectors revealed two distinct populations, i.e. dissociated and non-dissociated activity. Dyssynchronous activity (dissociated in time) increased from 17 ± 7% during acute AF to 39 ± 17% after 3 weeks, and 68 ± 13% after 6 months of AF. Dissociation was more pronounced in thicker parts of the atrial wall (thick: 49.3 ± 21.4%, thin: 42.2 ± 19.0%, P < 0.05). At baseline, endocardial ERPs were longer when compared with epicardial ERPs (ΔERP, 21.8 ± 18 ms; P < 0.001). This difference was absent after 6 months of AF. The percentage of fractionated electrograms during rapid pacing increased from 9.4 ± 1.9% (baseline) to 18.6 ± 0.6% (6 months).
CONCLUSION: During AF, pronounced dissociation of electrical activity occurs between the epicardial layer and the endocardial bundle network. The increase in dissociation is due to owing to progressive uncoupling between the epicardial layer and the endocardial bundles and correlates with increasing stability and complexity of the AF substrate.
Jens Eckstein; Bart Maesen; Dominik Linz; Stef Zeemering; Arne van Hunnik; Sander Verheule; Maurits Allessie; Ulrich Schotten
Related Documents :
11461736 - The relation between transmitral early filling wave deceleration time and the recovery ...
19808776 - Pro-arrhythmia in atrial fibrillation suppression pacing algorithms.
19712986 - Natriuretic peptides: useful biomarkers in predicting the possibility of restoration an...
17870006 - Adjunctive procedures in degenerative mitral valve repair: tricuspid valve and atrial f...
18048856 - Experimental model of lacunar infarction in the gyrencephalic brain of the miniature pi...
15556056 - Effect of valsartan added to background ace inhibitor therapy in patients with heart fa...
Publication Detail:
Type:  Journal Article     Date:  2010-10-26
Journal Detail:
Title:  Cardiovascular research     Volume:  89     ISSN:  1755-3245     ISO Abbreviation:  Cardiovasc. Res.     Publication Date:  2011 Mar 
Date Detail:
Created Date:  2011-02-17     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0077427     Medline TA:  Cardiovasc Res     Country:  England    
Other Details:
Languages:  eng     Pagination:  816-24     Citation Subset:  IM    
Department of Physiology, Maastricht University, Maastricht, The Netherlands.
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  Adiponectin protects against doxorubicin-induced cardiomyopathy by anti-apoptotic effects through AM...
Next Document:  Sirt1 inhibition promotes in vivo arterial thrombosis and tissue factor expression in stimulated cel...