Document Detail


Tight and adherens junctions in the ovine uterus: differential regulation by pregnancy and progesterone.
MedLine Citation:
PMID:  17478549     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
In species with noninvasive implantation by conceptus trophectoderm, fetal/maternal communications occur across the endometrial epithelia. The present studies identified changes in junctional complexes in the ovine endometrium that regulate paracellular trafficking of water, ions, and other molecules, and the secretory capacity of the uterine epithelia. Distinct temporal and spatial alterations in occludin, tight junction protein 2, and claudin 1-4 proteins were observed in the endometrium of cyclic and early pregnant ewes. Dynamic changes in tight junction formation were characterized by an abundance of tight junction proteins on d 10 of the estrous cycle and pregnancy that substantially decreased by d 12. Early progesterone administration advanced conceptus development on d 9 and 12 that was associated with loss of tight-junction-associated proteins. Pregnancy increased tight-junction-associated proteins between d 14-16. Cadherin 1 and beta-catenin, which form adherens junctions, were abundant in the endometrial glands, but decreased after d 10 of pregnancy in the luminal epithelium and then increased by d 16 with the onset of implantation. Results support the ideas that progesterone elicits transient decreases in tight and adherens junctions in the endometrial luminal epithelium between d 10-12 that increases selective serum and tissue fluid transudation to enhance blastocyst elongation, which is subsequently followed by an increase in tight and adherens junctions between d 14-16 that may be required for attachment and adherence of the trophectoderm for implantation. The continuous presence of tight and adherens junctions in the uterine glands would allow for vectorial secretion of trophic substances required for conceptus elongation and survival.
Authors:
M Carey Satterfield; Kathrin A Dunlap; Kanako Hayashi; Robert C Burghardt; Thomas E Spencer; Fuller W Bazer
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Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2007-05-03
Journal Detail:
Title:  Endocrinology     Volume:  148     ISSN:  0013-7227     ISO Abbreviation:  Endocrinology     Publication Date:  2007 Aug 
Date Detail:
Created Date:  2007-07-19     Completed Date:  2007-09-11     Revised Date:  2007-12-03    
Medline Journal Info:
Nlm Unique ID:  0375040     Medline TA:  Endocrinology     Country:  United States    
Other Details:
Languages:  eng     Pagination:  3922-31     Citation Subset:  AIM; IM    
Affiliation:
Center for Animal Biotechnology and Genomics, Department of Animal Science, Texas A&M University, College Station, Texas 77843-2471, USA.
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MeSH Terms
Descriptor/Qualifier:
Adherens Junctions / metabolism*
Animals
Cadherins / genetics,  metabolism
Embryo Implantation / physiology
Endometrium / cytology*,  physiology*
Female
Male
Membrane Proteins / metabolism
Pregnancy
Progesterone / metabolism*
RNA, Messenger / metabolism
Sheep
Tight Junctions / metabolism*
beta Catenin / genetics,  metabolism
Grant Support
ID/Acronym/Agency:
5 P30 ES09106/ES/NIEHS NIH HHS
Chemical
Reg. No./Substance:
0/Cadherins; 0/Membrane Proteins; 0/RNA, Messenger; 0/beta Catenin; 0/occludin; 0/zonula occludens-2 protein; 57-83-0/Progesterone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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