Document Detail


Tight Junction in Blood-Brain Barrier: An Overview of Structure, Regulation, and Regulator Substances.
MedLine Citation:
PMID:  22686334     Owner:  NLM     Status:  Publisher    
Abstract/OtherAbstract:
Blood-brain barrier (BBB) is a dynamic interference that regulates the nutrition and toxic substance in and out of the central nervous system (CNS), and plays a crucial role in maintaining a stable circumstance of the CNS. Tight junctions among adjacent cells form the basic structure of BBB to limiting paracellular permeability. In the present review, the constituents of tight junction proteins are depicted in detail, together with the regulation of tight junction under stimulation and in pathological conditions. Tight junction modulators are also discussed.
Authors:
Wei-Ye Liu; Zhi-Bin Wang; Li-Chao Zhang; Xin Wei; Ling Li
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-6-12
Journal Detail:
Title:  CNS neuroscience & therapeutics     Volume:  -     ISSN:  1755-5949     ISO Abbreviation:  -     Publication Date:  2012 Jun 
Date Detail:
Created Date:  2012-6-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101473265     Medline TA:  CNS Neurosci Ther     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
© 2012 Blackwell Publishing Ltd.
Affiliation:
Department of Pharmacology, Second Military Medical University, Shanghai, China Department of Pharmacy, Shanghai Seventh People's Hospital, Shanghai, China.
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