Document Detail


Tienilic acid: a single treatment for hyperuricaemia and hypertension?
MedLine Citation:
PMID:  7436564     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tienilic acid is a drug with established uricosuric and hypotensive properties. We have examined its potential role as a single treatment for hyperuricaemia and hypertension, 2 disorders which are commonly associated. In 17 subjects with gout, blood uric acid levels were reduced by approximately 50%. Eleven of these patients also had hypertension which was improved by tienilic acid. However, a statistically significant effect was observed only with standing diastolic blood pressure. Side effects included acute episodes of gout in 4 patients and transient loin pain and dysuria in 1 patient. The precipitation of gouty arthritis is an acknowledged risk of all potent hypouricaemic drugs. The hazard of urate deposition in the renal tract implicit in the history of loin pain is a more serious complication. Thus, it would appear that tienilic acid is a potentially valuable drug which may have a special role in patients with hyperuricaemia and hypertension. Further study is necessary to determine how it may be best administered without the risk of renal damage.
Authors:
T Gibson; V A Rodgers; C F Potter; H A Simmonds
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of the rheumatic diseases     Volume:  39     ISSN:  0003-4967     ISO Abbreviation:  Ann. Rheum. Dis.     Publication Date:  1980 Aug 
Date Detail:
Created Date:  1981-01-26     Completed Date:  1981-01-26     Revised Date:  2013-04-11    
Medline Journal Info:
Nlm Unique ID:  0372355     Medline TA:  Ann Rheum Dis     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  373-6     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure
Glycolates / therapeutic use*
Gout / complications
Humans
Hypertension / blood,  complications,  drug therapy*
Male
Middle Aged
Ticrynafen / therapeutic use*
Time Factors
Uric Acid / blood*
Chemical
Reg. No./Substance:
0/Glycolates; 40180-04-9/Ticrynafen; 69-93-2/Uric Acid
Comments/Corrections

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