Document Detail

Tidal volume single-breath washin of SF6 and CH4 in transient microgravity.
MedLine Citation:
PMID:  12391087     Owner:  NLM     Status:  MEDLINE    
We performed tidal volume single-breath washins (SBW) by using tracers of different diffusivity and varied the time spent in microgravity (microG) before the start of the tests to look for time-dependent effects. SF(6) and CH(4) phase III slopes decreased by 35 and 26%, respectively, in microG compared with 1 G (P < 0.05), and the slope difference between gases disappeared. There was no effect of time in microG, suggesting that neither the hypergravity period preceding microG nor the time spent in microG affected gas mixing at volumes near functional residual capacity. In previous studies using SF(6) and He (Lauzon A-M, Prisk GK, Elliott AR, Verbanck S, Paiva M, and West JB. J Appl Physiol 82: 859-865, 1997), the vital capacity SBW showed an increase in slope difference between gases in transient microG, the opposite of the decrease in sustained microG. In contrast, tidal volume SBW showed a decrease in slope difference in both microG conditions. Because it is only the behavior of the more diffusive gas that differed between maneuvers and microG conditions, we speculate that, in the previous vital capacity SBW, the hypergravity period preceding the test in transient microG provoked conformational changes at low lung volumes near the acinar entrance.
Brigitte Dutrieue; Manuel Paiva; Sylvia Verbanck; Marine Le Gouic; Chantal Darquenne; G Kim Prisk
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.     Date:  2002-09-06
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  94     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2003 Jan 
Date Detail:
Created Date:  2002-12-17     Completed Date:  2003-06-20     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  75-82     Citation Subset:  IM; S    
Biomedical Physics Laboratory, Université Libre de Bruxelles, 1070, Belgium.
Space Flight Mission:
Flight Experiment; Parabolic Flight; manned; short duration
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MeSH Terms
Sulfur Hexafluoride*
Tidal Volume
Time Factors
Reg. No./Substance:
2551-62-4/Sulfur Hexafluoride; 74-82-8/Methane
G K Prisk / U CA San Diego, La Jolla

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