Document Detail

Tidal volume perception in normal subjects: the effect of altered arterial PCO2.
MedLine Citation:
PMID:  8023024     Owner:  NLM     Status:  MEDLINE    
We examined the relationship between tidal volume (VT) perception and level of CO2. Ten normal subjects were connected to a volume-cycled ventilator set in control mode, and VT and respiratory rate were adjusted until subjects were comfortable. At 2 levels of CO2 which differed by 6-8 mmHg, subjects rated ten different ventilator tidal volumes which ranged from 40-200% of the VT that made them comfortable at the lower CO2. Despite large differences in inspiratory muscle activity, there was no significant difference between the two levels of CO2 for either the exponent [1.39 +/- 0.35 vs 1.36 +/- 0.49 (low CO2 vs high CO2, mean +/- SD), P > 0.5] or constant (-0.09 +/- 0.12 vs -0.14 +/- 0.17, P > 0.1) for VT perception. For the group, there was no correlation between the hypercapnic ventilatory response (HCVR) measured by rebreathing and the exponent for VT perception. We conclude that: (1) the level of CO2 does not influence magnitude estimation of VT; (2) respiratory muscle activity is not essential to VT perception; and (3) there is no correlation between the HCVR and magnitude estimation of VT.
H L Manning; S Slogic; J C Leiter
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Respiration physiology     Volume:  96     ISSN:  0034-5687     ISO Abbreviation:  Respir Physiol     Publication Date:  1994 Apr 
Date Detail:
Created Date:  1994-08-02     Completed Date:  1994-08-02     Revised Date:  2009-11-11    
Medline Journal Info:
Nlm Unique ID:  0047142     Medline TA:  Respir Physiol     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  99-110     Citation Subset:  IM    
Department of Medicine, Dartmouth-Hitchcock Medical Center, Lebanon, NH 03756.
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MeSH Terms
Blood Gas Analysis
Carbon Dioxide / blood*,  physiology
Hypercapnia / physiopathology
Partial Pressure
Respiration / physiology*
Tidal Volume / physiology
Reg. No./Substance:
124-38-9/Carbon Dioxide

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