Document Detail

Tidal volume inflection and its sensory consequences during exercise in patients with stable asthma.
MedLine Citation:
PMID:  23026436     Owner:  NLM     Status:  Publisher    
Sixteen patients with stable asthma performed a symptom-limited constant work-rate CWR cycle exercise during which breathing pattern, operating lung volumes, dyspnea intensity and its qualitative descriptors were measured. An inflection in the relation between tidal volume (VT) and ventilation (V˙E) was observed in each subject. The sense of "work/effort" was the dominant dyspnea descriptor selected up to the VT/V˙E inflection, whereas after it dyspnea intensity and the selection frequency of "unsatisfied inspiration" rose steeply in 37.5% of subjects in whom inspiratory reserve volume (IRV) had decreased to a critical level of 0.6L at the VT inflection point. In contrast, dyspnea increased linearly with exercise time and V˙E, and "work/effort" was the dominant descriptor selected throughout exercise in 62.5% of subjects in whom the VT/V˙E inflection occurred at a preserved IRV The VT inflection during exercise in patients with stable asthma marked a mechanical event with important sensory consequences only when it occurred at a critical reduced IRV.
Pierantonio Laveneziana; Giulia Innocenti Bruni; Ilenia Presi; Loredana Stendardi; Roberto Duranti; Giorgio Scano
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Publication Detail:
Type:  JOURNAL ARTICLE     Date:  2012-9-28
Journal Detail:
Title:  Respiratory physiology & neurobiology     Volume:  -     ISSN:  1878-1519     ISO Abbreviation:  Respir Physiol Neurobiol     Publication Date:  2012 Sep 
Date Detail:
Created Date:  2012-10-2     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101140022     Medline TA:  Respir Physiol Neurobiol     Country:  -    
Other Details:
Languages:  ENG     Pagination:  -     Citation Subset:  -    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
Univ Paris 06, Equipe de Recherche ER 10 UPMC, Laboratoire de Physio-Pathologie Respiratoire, Faculté de Médecine Pierre et Marie Curie (site Pitié-Salpêtrière), Paris, 75013, France; Univ Paris-Sud, Faculté de médecine, Le Kremlin-Bicêtre, 94276, France; INSERM U999, Centre Chirurgical Marie Lannelongue, Le Plessis-Robinson, 92350, France. Electronic address:
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