Document Detail

Tidal exhaled nitric oxide in healthy, unsedated newborn infants with prenatal tobacco exposure.
MedLine Citation:
PMID:  11744643     Owner:  NLM     Status:  MEDLINE    
Tidal fractional exhaled nitric oxide (FE(NO)) changes were investigated in healthy, unsedated infants with or without prenatal tobacco exposure. Tidal flow (V), FE(NO), and CO(2) were measured in 20 healthy, unsedated infants [age: 25-58 days, length: 56.5 +/- 2.5 (SE) cm]. NO output (VNO) was calculated (VNO = FE(NO) x V). Two approaches were used to investigate within-breath changes of FE(NO) and VNO. First, we identified phases II and III from the expiratory capnogram. Second, we divided expiration into time-based quartiles. Tidal FE(NO) (range: 14.5 +/- 1.6 to 17.6 +/- 2.1 parts/billion: quartile 4 and phase II, respectively) was not different between portions and exhibited significant negative V dependence. VNO was significantly dependent on the expiratory portion, with quartile 4 being significantly lower than the remaining expiratory portions. Infants exposed to prenatal cigarette smoke (n = 7) exhibited significantly lower FE(NO) and VNO compared with nonexposed (n = 13) infants. We conclude that tidal FE(NO) is V dependent and that VNO may be a more suitable outcome parameter in variable V conditions. Prenatal tobacco exposure resulted in a decreased FE(NO) and VNO in infants.
Graham L Hall; Benjamin Reinmann; Johannes H Wildhaber; Urs Frey
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of applied physiology (Bethesda, Md. : 1985)     Volume:  92     ISSN:  8750-7587     ISO Abbreviation:  J. Appl. Physiol.     Publication Date:  2002 Jan 
Date Detail:
Created Date:  2001-12-17     Completed Date:  2002-04-10     Revised Date:  2013-09-26    
Medline Journal Info:
Nlm Unique ID:  8502536     Medline TA:  J Appl Physiol (1985)     Country:  United States    
Other Details:
Languages:  eng     Pagination:  59-66     Citation Subset:  IM    
Swiss Paediatric Respiratory Physiology Research Group, University Children's Hospital Bern, CH-3010 Bern, Switzerland.
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MeSH Terms
Carbon Dioxide / metabolism
Infant, Newborn
Nitric Oxide / metabolism*
Prenatal Exposure Delayed Effects*
Respiratory Function Tests
Respiratory Mechanics / physiology
Sleep / physiology
Tobacco Smoke Pollution / adverse effects*
Reg. No./Substance:
0/Tobacco Smoke Pollution; 10102-43-9/Nitric Oxide; 124-38-9/Carbon Dioxide

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