Document Detail

Tidal breathing model describing end-tidal, alveolar, arterial and mixed venous CO(2) and O(2).
MedLine Citation:
PMID:  20554075     Owner:  NLM     Status:  In-Data-Review    
Thermodilution is the current standard for determination of cardiac output. The method is invasive and constitutes a risk for the patient. As an alternative CO(2) rebreathing allows non-invasive cardiac output estimation using Ficks principle. The method relies on estimation of arterial CO(2) partial pressure from end-tidal CO(2) pressure and estimation of mixed venous CO(2) partial pressure from end-tidal CO(2) during rebreathing. Presumably the oxygenation of blood in the lung capillaries increases lung capillary CO(2) pressure due to the Haldane effect, which during rebreathing may result in overestimation of the mixed venous CO(2) pressure. However, the Haldane effect is not discussed in the current literature describing cardiac output estimation using CO(2) rebreathing. The purpose of this study is to construct and verify a compartmental tidal breathing lung model to investigate the physiological mechanisms that influence the CO(2) rebreathing technique. The model simulations show agreement with previous studies describing end-tidal to arterial differences in CO(2) pressure and rebreathing with high and low O(2) fractions in the rebreathing bag. In conclusion the simulations show that caution has to be taken when using end-tidal measurements to estimate CO(2) pressures, especially during rebreathing where the Haldane effect causes mixed venous CO(2) partial pressure to be substantially overestimated.
Peter Poulsen; Dan S Karbing; Stephen E Rees; Steen Andreassen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Computer methods and programs in biomedicine     Volume:  101     ISSN:  1872-7565     ISO Abbreviation:  Comput Methods Programs Biomed     Publication Date:  2011 Feb 
Date Detail:
Created Date:  2011-02-22     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  8506513     Medline TA:  Comput Methods Programs Biomed     Country:  Ireland    
Other Details:
Languages:  eng     Pagination:  166-72     Citation Subset:  IM    
Copyright Information:
Copyright © 2010 Elsevier Ireland Ltd. All rights reserved.
Center for Model-Based Medical Decision Support, Aalborg University, Niels Jernes Vej 14, DK-9220 Aalborg East, Denmark.
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