Document Detail


Ticrynafen and hydrochlorothiazide. A double-blind study of antihypertensive properties with an open crossover.
MedLine Citation:
PMID:  372609     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Twenty-eight patients completed a double-blind study of the antihypertensive effects of ticrynafen compared with those of hydrochlorothiazide. The results of blood pressure reduction were comparable in the two groups. After six months, 12 patients were crossed over to ticrynafen therapy from hydrochlorothiazide. They maintained their blood pressure reduction. The most striking difference between the two groups was in the uric acid response. The uric acid level in the patients receiving hydrochlorothiazide therapy rose from a baseline of 5.9 to 7.5 mg/dL (normal range, 3.0 to 8.0 mg/dL). The uric acid level of those patients receiving ticrynafen therapy decreased from a baseline of 6.4 mg/dL to a low of 3.3 mg/dL. In view of ticrynafen's appreciable antihypertensive and uric-acid-lowering effects, it appears to be a useful new antihypertensive drug.
Authors:
S A Miller; V Vertes
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  JAMA     Volume:  241     ISSN:  0098-7484     ISO Abbreviation:  JAMA     Publication Date:  1979 May 
Date Detail:
Created Date:  1979-06-29     Completed Date:  1979-06-29     Revised Date:  2014-09-17    
Medline Journal Info:
Nlm Unique ID:  7501160     Medline TA:  JAMA     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  2174-6     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adult
Aged
Blood Pressure
Clinical Trials as Topic
Diuretics / therapeutic use*
Double-Blind Method
Female
Glycolates / therapeutic use*
Humans
Hydrochlorothiazide / therapeutic use*
Hypertension / blood,  diagnosis,  drug therapy*
Male
Middle Aged
Phenoxyacetates / therapeutic use*
Placebos
Thiophenes / therapeutic use*
Uric Acid / blood
Chemical
Reg. No./Substance:
0/Diuretics; 0/Glycolates; 0/Phenoxyacetates; 0/Placebos; 0/Thiophenes; 0J48LPH2TH/Hydrochlorothiazide; 268B43MJ25/Uric Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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