Document Detail


Ticlopidine-induced aplastic anemia and quick recovery with G-CSF: case report and literature review.
MedLine Citation:
PMID:  10629575     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
We report here a case of ticlopidine-induced aplastic anemia that responded to G-CSF and review the literature. An 83-year-old woman was started on ticlopidine for coronary artery disease after an episode of upper gastrointestinal bleeding secondary to aspirin. She developed aplastic anemia seven weeks after initiation of ticlopidine. She was hospitalised and received empiric antibiotic therapy and granulocyte colony stimulating factor (G-CSF). Her bone marrow started to recover quickly, and white blood cell and platelet counts returned to normal within three weeks. A review of medical literature revealed 20 similar cases of ticlopidine-induced aplastic anemia resulting in death in seven cases. G-CSF has been used previously with variable success. Ticlopidine is associated with serious, sometimes fatal hematological side effects. This risk should be seriously taken into consideration when prescribing ticlopidine. G-CSF may be helpful in the treatment of ticlopidine-induced aplastic anemia.
Authors:
A Taher; Z Ammash; B Dabajah; A Nasrallah; F H Mourad
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  American journal of hematology     Volume:  63     ISSN:  0361-8609     ISO Abbreviation:  Am. J. Hematol.     Publication Date:  2000 Feb 
Date Detail:
Created Date:  2000-02-16     Completed Date:  2000-02-16     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  7610369     Medline TA:  Am J Hematol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  90-3     Citation Subset:  IM    
Copyright Information:
Copyright 2000 Wiley-Liss, Inc.
Affiliation:
Department of Internal Medicine, American University of Beirut Medical Center, Beirut, Lebanon. ataher@aub.edu.lb
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MeSH Terms
Descriptor/Qualifier:
Aged
Aged, 80 and over
Anemia, Aplastic / chemically induced*,  diagnosis,  drug therapy*
Aspirin / adverse effects
Bone Marrow Cells / drug effects
Coronary Disease / complications,  drug therapy
Female
Gastrointestinal Hemorrhage / chemically induced
Granulocyte Colony-Stimulating Factor / therapeutic use*
Humans
Kidney Failure, Chronic / complications
Leukocyte Count / drug effects
Platelet Aggregation Inhibitors / adverse effects*
Platelet Count / drug effects
Ticlopidine / adverse effects*
Chemical
Reg. No./Substance:
0/Platelet Aggregation Inhibitors; 143011-72-7/Granulocyte Colony-Stimulating Factor; 50-78-2/Aspirin; 55142-85-3/Ticlopidine

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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