Document Detail

Ticlopidine-associated aplastic anemia. A case report and review of literature.
MedLine Citation:
PMID:  9540764     Owner:  NLM     Status:  MEDLINE    
Serious hematologic complications associated with ticlopidine have been reported, including aplastic anemia. We report here an additional case of fatal aplastic anemia due to ticlopidine. A 66-year-old male patient developed fever and pancytopenia 2 months after ticlopidine was started. Despite the administration of granulocyte colony-stimulating factor (G-CSF) and broad-spectrum antibiotics, as well as aggressive red cell and platelet transfusions, the patient died 16 days after admission due to septic shock. Eighteen other cases of ticlopidine-induced aplastic anemia published in the English literature are also reviewed and presented here. Eight of the total 19 patients (including the one reported here) have died, mostly due to infection. Of the seven who received supportive treatment only, four had spontaneous recovery. Nine cases were treated with G-CSF or granulocyte-macrophage colony-stimulating factor (GM-CSF), and response was observed in only four of them. Several other cases were treated with high-dose corticosteroids or androgens; however, it was not possible to evaluate the efficacy of these treatments because of the limited number of cases. In the absence of satisfactory treatment for ticlopidine-induced aplastic anemia at present, it may be reasonable to try antilymphocyte globulin or cyclosporine. Also, great efforts should be made in the prevention and management of infection accompanying this disease.
S P Yeh; E J Hsueh; H Wu; Y C Wang
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Publication Detail:
Type:  Case Reports; Journal Article; Review    
Journal Detail:
Title:  Annals of hematology     Volume:  76     ISSN:  0939-5555     ISO Abbreviation:  Ann. Hematol.     Publication Date:  1998 Feb 
Date Detail:
Created Date:  1998-04-23     Completed Date:  1998-04-23     Revised Date:  2005-11-16    
Medline Journal Info:
Nlm Unique ID:  9107334     Medline TA:  Ann Hematol     Country:  GERMANY    
Other Details:
Languages:  eng     Pagination:  87-90     Citation Subset:  IM    
Department of Internal Medicine, Veterans General Hospital-Kaoshiung, Taiwan, R.O.C.
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MeSH Terms
Adrenal Cortex Hormones / therapeutic use
Anemia, Aplastic / chemically induced*,  complications,  drug therapy
Fatal Outcome
Granulocyte Colony-Stimulating Factor / therapeutic use
Granulocyte-Macrophage Colony-Stimulating Factor / therapeutic use
Platelet Aggregation Inhibitors / adverse effects*
Shock, Septic / etiology
Ticlopidine / adverse effects*
Reg. No./Substance:
0/Adrenal Cortex Hormones; 0/Platelet Aggregation Inhibitors; 143011-72-7/Granulocyte Colony-Stimulating Factor; 55142-85-3/Ticlopidine; 83869-56-1/Granulocyte-Macrophage Colony-Stimulating Factor

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