Document Detail


Tick salivary secretion as a source of antihemostatics.
MedLine Citation:
PMID:  22564820     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Ticks are mostly obligatory blood feeding ectoparasites that have an impact on human and animal health. In addition to direct damage due to feeding, some tick species serve as the vectors for the causative agents of several diseases, such as the spirochetes of the genus Borrelia causing Lyme disease, the virus of tick-borne encephalitis, various Rickettsial pathogens or even protozoan parasites like Babesia spp. Hard ticks are unique among bloodfeeders because of their prolonged feeding period that may last up to two weeks. During such a long period of blood uptake, the host develops a wide range of mechanisms to prevent blood loss. The arthropod ectoparasite, in turn, secretes saliva in the sites of bite that assists blood feeding. Indeed, tick saliva represents a rich source of proteins with potent pharmacologic action that target different mechanisms of coagulation, platelet aggregation and vasoconstriction. Tick adaptation to their vertebrate hosts led to the inclusion of a powerful protein armamentarium in their salivary secretion that has been investigated by high-throughput methods. The resulting knowledge can be exploited for the isolation of novel antihemostatic agents. Here we review the tick salivary antihemostatics and their characterized functions at the molecular and cellular levels.
Authors:
Jindrich Chmelar; Eric Calvo; Joao H F Pedra; Ivo M B Francischetti; Michail Kotsyfakis
Publication Detail:
Type:  Journal Article; Research Support, N.I.H., Extramural; Research Support, N.I.H., Intramural; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Review     Date:  2012-04-27
Journal Detail:
Title:  Journal of proteomics     Volume:  75     ISSN:  1876-7737     ISO Abbreviation:  J Proteomics     Publication Date:  2012 Jul 
Date Detail:
Created Date:  2012-06-25     Completed Date:  2012-10-29     Revised Date:  2013-12-06    
Medline Journal Info:
Nlm Unique ID:  101475056     Medline TA:  J Proteomics     Country:  Netherlands    
Other Details:
Languages:  eng     Pagination:  3842-54     Citation Subset:  IM    
Copyright Information:
Copyright © 2012 Elsevier B.V. All rights reserved.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anti-Inflammatory Agents / pharmacology
Arachnid Vectors / virology
Hemostatics / antagonists & inhibitors*
Humans
Proteome / chemistry
Saliva / chemistry*
Serine Proteinase Inhibitors / chemistry
Ticks / virology*
Grant Support
ID/Acronym/Agency:
R01 AI093653/AI/NIAID NIH HHS; R01AI093653/AI/NIAID NIH HHS
Chemical
Reg. No./Substance:
0/Anti-Inflammatory Agents; 0/Hemostatics; 0/Proteome; 0/Serine Proteinase Inhibitors
Comments/Corrections

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