| Tick salivary gland extract inhibits killing of Borrelia afzelii spirochetes by mouse macrophages. | |
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MedLine Citation:
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PMID: 11119556 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Salivary gland extract (SGE) from Ixodes ricinus ticks inhibited the killing of Borrelia afzelii spirochetes by murine macrophages. SGE also reduced the production of two major defense molecules of phagocytes, superoxide and nitric oxide. It is likely that the suppression of macrophage microbicidal mechanisms contributes to the inhibitory effect of tick saliva on the killing of B. afzelii spirochetes, thus facilitating the transmission of this important pathogen. |
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Authors:
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M Kuthejlová; J Kopecký; G Stepánová; A Macela |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't |
Journal Detail:
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Title: Infection and immunity Volume: 69 ISSN: 0019-9567 ISO Abbreviation: Infect. Immun. Publication Date: 2001 Jan |
Date Detail:
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Created Date: 2001-01-18 Completed Date: 2001-01-18 Revised Date: 2013-04-17 |
Medline Journal Info:
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Nlm Unique ID: 0246127 Medline TA: Infect Immun Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 575-8 Citation Subset: IM |
Affiliation:
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Institute of Parasitology, Academy of Sciences of the Czech Republic, Czech Republic. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Borrelia / immunology* Female Ixodes / physiology* Macrophages / immunology* Mice Mice, Inbred BALB C Saliva / physiology* |
| Comments/Corrections | |
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