Document Detail


Tick-borne relapsing fever in a new highland endemic focus of western Iran.
MedLine Citation:
PMID:  19695158     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Tick-borne relapsing fever (TBRF) is a neglected zoonotic disease caused by infection with spirochaetes of the genus Borrelia. Humans usually contract it from the bite of infected soft ticks of the genus Ornithodoros. In Iran, where the disease is endemic in the mountainous north-western provinces, reports of over 200 cases annually probably under-estimate the true incidence. The species, distribution and infection of ticks that are potential vectors of Borrelia and the clinical and epidemiological characteristics of the local TBRF cases were recently investigated in the villages in and around the county town of Bijar, in north-western Iran. A blood sample from each suspected case of TBRF was checked for B. persica by dark-field microscopy, data were collected on the demographics and clinical manifestations of each confirmed case, and the prevalence of tick infection with borreliae and the monthly incidence of TBRF were evaluated. Between 2000 and 2007, 148 cases of TBRF (each with fever, chills and headache) were passively detected in the town. Most (115) of these were confirmed by microscopy, with the other subjects categorized as probable (21) or suspected cases (12) of TBRF. Most (91%) of the 148 subjects were young people, and most came from rural areas and lived in large households in the old mud-and-thatch houses of Bijar. Most (82%) of the cases occurred during the summer or early autumn. Overall, 8543 soft ticks (Ornithodoros tholozani, O. lahorensis, Argas persicus and A. reflexus) were collected by clustered random sampling. When a random sample of the O. tholozani ticks (96 of the 577 collected) was checked for B. persica infection, by being crushed and then inoculated intraperitoneally into a mouse or suckling Syrian hamster, 19 were found infected. Peaks in the monthly incidence of TBRF occurred as the numbers of O. tholozani in the tick collections peaked, and it seems likely that most of the cases were caused by B. persica transmitted by O. tholozani. Further studies in Iran, to map the geographical variation in the prevalence of soft-tick infection with Borrelia and identify any Borrelia reservoirs, are recommended.
Authors:
M D Moemenbellah-Fard; O Benafshi; J Rafinejad; H Ashraf
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Annals of tropical medicine and parasitology     Volume:  103     ISSN:  1364-8594     ISO Abbreviation:  Ann Trop Med Parasitol     Publication Date:  2009 Sep 
Date Detail:
Created Date:  2009-08-21     Completed Date:  2010-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  2985178R     Medline TA:  Ann Trop Med Parasitol     Country:  England    
Other Details:
Languages:  eng     Pagination:  529-37     Citation Subset:  IM    
Affiliation:
Department of Medical Entomology, Research Centre for Health Sciences, School of Health and Nutrition, Shiraz University of Medical Sciences, Shiraz, Iran. momenbf@yahoo.com
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MeSH Terms
Descriptor/Qualifier:
Adolescent
Adult
Animals
Argasidae / genetics,  pathogenicity*
Child
Child, Preschool
Cricetinae
Cross-Sectional Studies
Endemic Diseases
Housing / standards
Humans
Infant
Iran / epidemiology
Mice
Prevalence
Relapsing Fever / epidemiology*,  prevention & control
Seasons
Tick Infestations / epidemiology*
Young Adult

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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