| The tick salivary protein sialostatin L inhibits the Th9-derived production of the asthma-promoting cytokine IL-9 and is effective in the prevention of experimental asthma. | |
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MedLine Citation:
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PMID: 22327077 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Ticks developed a multitude of different immune evasion strategies to obtain a blood meal. Sialostatin L is an immunosuppressive cysteine protease inhibitor present in the saliva of the hard tick Ixodes scapularis. In this study, we demonstrate that sialostatin L strongly inhibits the production of IL-9 by Th9 cells. Because we could show recently that Th9-derived IL-9 is essentially involved in the induction of asthma symptoms, sialostatin L was used for the treatment of experimental asthma. Application of sialostatin L in a model of experimental asthma almost completely abrogated airway hyperresponsiveness and eosinophilia. Our data suggest that sialostatin L can prevent experimental asthma, most likely by inhibiting the IL-9 production of Th9 cells. Thus, alternative to IL-9 neutralization sialostatin L provides the basis for the development of innovative therapeutic strategies to treat asthma. |
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Authors:
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Helena Horka; Valérie Staudt; Matthias Klein; Christian Taube; Sebastian Reuter; Nina Dehzad; John F Andersen; Jan Kopecky; Hansjörg Schild; Michalis Kotsyfakis; Markus Hoffmann; Bastian Gerlitzki; Michael Stassen; Tobias Bopp; Edgar Schmitt |
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Publication Detail:
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Type: Journal Article; Research Support, Non-U.S. Gov't Date: 2012-02-10 |
Journal Detail:
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Title: Journal of immunology (Baltimore, Md. : 1950) Volume: 188 ISSN: 1550-6606 ISO Abbreviation: J. Immunol. Publication Date: 2012 Mar |
Date Detail:
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Created Date: 2012-03-05 Completed Date: 2012-04-19 Revised Date: 2013-04-18 |
Medline Journal Info:
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Nlm Unique ID: 2985117R Medline TA: J Immunol Country: United States |
Other Details:
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Languages: eng Pagination: 2669-76 Citation Subset: AIM; IM |
Affiliation:
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Institute of Parasitology, Biology Centre of the Academy of Sciences of the Czech Republic and Faculty of Science, University of South Bohemia, 37005 České Budějovice, Czech Republic. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Animals Asthma / immunology*, metabolism, prevention & control Cell Separation Cystatins / immunology*, pharmacology Cytokines / immunology, metabolism Disease Models, Animal Enzyme-Linked Immunosorbent Assay Female Flow Cytometry Interleukin-9 / biosynthesis, immunology* Ixodidae / immunology* Male Mice Mice, Inbred BALB C Mice, Knockout Real-Time Polymerase Chain Reaction Reverse Transcriptase Polymerase Chain Reaction T-Lymphocyte Subsets / immunology*, metabolism |
| Grant Support | |
ID/Acronym/Agency:
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Z01 AI001012-01/AI/NIAID NIH HHS; Z01 AI001012-02/AI/NIAID NIH HHS; ZIA AI001012-03/AI/NIAID NIH HHS; ZIA AI001012-04/AI/NIAID NIH HHS; ZIA AI001012-05/AI/NIAID NIH HHS; ZIA AI001012-06/AI/NIAID NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Cystatins; 0/Cytokines; 0/Interleukin-9; 0/sialostatin L, Ixodes scapularis |
| Comments/Corrections | |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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