| Tibolone in postmenopausal women with systemic lupus erythematosus: a pilot study. | |
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MedLine Citation:
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PMID: 19193505 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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OBJECTIVE: To determine the influence of the use of tibolone on the frequency of flares of systemic lupus erythematosus (SLE) in postmenopausal patients. METHODS: Thirty patients with inactive or controlled SLE were included in the study. Patients were randomized to receive a 12-month course of either tibolona (2.5 mg/day) or placebo. The following were investigated: hypoestrogenism symptoms by Kupperman index, weight; anti-dsDNA antibodies; SLE flares (frequency) assessed by the Systemic Lupus Erythematosus Disease Activity Index (SLEDAI); and biochemical profile (total cholesterol, high-density lipoprotein cholesterol [HDL-C], triglycerides, complement components [C3/C4], alpha1-acid glycoprotein, urea, creatinine, 24-h proteinuria, C-reactive protein and erythrocyte sedimentation rate). RESULTS: The reduction in Kupperman index was greater in the patients using tibolone than in those using placebo. The mean SLEDAI was not different between the groups during the study as well as SLE flare frequency (tibolone: 2/15 [13.3%] vs. placebo: 1/15 [6.7%]; p=0.54). All cases of flares were considered mild to moderate. Although the groups were similar at the baseline evaluation, after 6 and 12 months of treatment lower values were found in the tibolone group for triglycerides (6 months: 161.6+/-30.9 mg/dl vs. 194.4+/-46.5; p=0.04; 12 months 163.7+/-29.8 mg/dl vs. 204.1+/-49.9 mg/dl; p=0.02; tibolone vs. placebo group, respectively) and for HDL-C (6 months: 40.7+/-10.7 mg/dl vs. 53.4+/-16.5; p=0.02; 12 months: 47.2+/-7.9 mg/dl vs. 63.2+/-16.3mg/dl; p<0.01; tibolone vs. placebo group, respectively). There were no differences between the two groups in any of the remaining variables. CONCLUSION: In patients with inactive or stable SLE, the short-term use of tibolone did not significantly affect the frequency of flares. In addition, tibolone was well tolerated and effective to control hypoestrogenism related symptoms in SLE patients. |
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Authors:
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Carolina Sales Vieira; Fábio Vasconcelos Pereira; Marcos Felipe Silva de Sá; Louzada Júnior Paulo; Wellington Paula Martins; Rui Alberto Ferriani |
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Publication Detail:
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Type: Journal Article; Randomized Controlled Trial Date: 2009-02-03 |
Journal Detail:
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Title: Maturitas Volume: 62 ISSN: 1873-4111 ISO Abbreviation: Maturitas Publication Date: 2009 Mar |
Date Detail:
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Created Date: 2009-03-30 Completed Date: 2009-06-11 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 7807333 Medline TA: Maturitas Country: Ireland |
Other Details:
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Languages: eng Pagination: 311-6 Citation Subset: IM |
Affiliation:
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Department of Gynecology and Obstetrics at the University of São Paulo, Ribeirão Preto School of Medicine, Ribeirão Preto, Brazil. carol.sales@uol.com.br |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Cholesterol, HDL
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blood Double-Blind Method Estrogen Receptor Modulators / therapeutic use* Estrogen Replacement Therapy* Estrogens / blood, deficiency* Female Humans Lupus Erythematosus, Systemic / blood, drug therapy* Middle Aged Norpregnenes / therapeutic use* Pilot Projects Postmenopause / blood Severity of Illness Index Treatment Outcome Triglycerides / blood |
| Chemical | |
Reg. No./Substance:
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0/Cholesterol, HDL; 0/Estrogen Receptor Modulators; 0/Estrogens; 0/Norpregnenes; 0/Triglycerides; 5630-53-5/tibolone |
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