Document Detail

Tibetans retained innate ability resistance to acute hypoxia after long period of residing at sea level.
MedLine Citation:
PMID:  18413013     Owner:  NLM     Status:  MEDLINE    
Could the intrinsic characteristics of tolerance to hypoxia be retained in Tibetan high-altitude natives after they had migrated to a low altitude? To answer this question, we undertook a study of 33 healthy male adolescent Tibetans born and raised in a high plateau (3,700 m [12,140 ft] above sea level) who migrated to Shanghai (sea level) for 4 years. Ten age-matched healthy male Han adolescents born and raised in Shanghai were regarded as the control group. Acute hypoxia was induced in a hypobaric chamber for 2 h to simulate the 3,700 m altitude. At sea level, maximal oxygen consumption (VO2 max) was not significantly different between the two groups. During acute hypoxia, the values of VO2 max, tissue oxygen extraction, arterial oxygen pressure, and the arterial oxygen saturation showed markedly higher in Tibetan subjects than in Han subjects (1.41 +/- 0.04 l/min/M2 vs.1.25 +/- 0.04 l/min/M2, 55.0 +/- 4.2% vs. 47.3 +/- 9.1%, 7.2 +/- 0.6 vs. 5.5 +/- 0.2 kPa, and 87.9 +/- 3.3% vs. 78.2 +/- 1.6%, respectively, P < 0.05). The calculated "oxygen reserve capacity" and "cardiac reserve capacity" were better in the Tibetans than in the Han natives (P < 0.05), which suggests that physical work capacity is greater in the Tibetan group. The sympathetic stimulation was less, and there was no noticeable change in cardiac function during acute hypoxia in the Tibetan group. The results indicate that the better tolerance to hypoxia in the Tibetans is retained during the 4-year stay at sea level, implying that the intrinsic hypoxic adaptation still exists in the Tibetan high-altitude natives.
Zhao-Nian Zhou; Jian-Guo Zhuang; Xiu-Feng Wu; Yi Zhang; Pipat Cherdrungsi
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2008-04-17
Journal Detail:
Title:  The journal of physiological sciences : JPS     Volume:  58     ISSN:  1880-6546     ISO Abbreviation:  J Physiol Sci     Publication Date:  2008 Jun 
Date Detail:
Created Date:  2008-06-16     Completed Date:  2008-10-16     Revised Date:  2008-12-29    
Medline Journal Info:
Nlm Unique ID:  101262417     Medline TA:  J Physiol Sci     Country:  Japan    
Other Details:
Languages:  eng     Pagination:  167-72     Citation Subset:  IM    
Laboratory of Hypoxic Cardiovascular Physiology, Shanghai Institutes for Biological Science, (Shanghai Institute of Physiology), Chinese Academy of Sciences, Shanghai 200031, China.
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MeSH Terms
Anoxia / blood,  ethnology*
Disease Susceptibility
Heart Rate / physiology
Oxygen / blood
Oxygen Consumption / physiology
Sympathetic Nervous System / physiology
Tibet / ethnology
Time Factors
Reg. No./Substance:

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