Document Detail


Tibetan and Andean contrasts in adaptation to high-altitude hypoxia.
MedLine Citation:
PMID:  10849649     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
High-altitude environments provide natural experimental settings to investigate adaptation to environmental stress. An important evolutionary and functional question is whether sea-level human biology constrains the adaptive response. This paper presents evidence that indigenous populations of the Tibetan and Andean plateaus exhibit quantitatively different responses to hypobaric hypoxic stress. At the same altitude, Tibetan mean resting ventilation and hypoxic ventilatory response were more than one-half standard deviation higher than Andean Aymara means while Tibetan mean oxygen saturation and hemoglobin concentration were more than one standard deviation below the Andean means. Quantitative genetic analyses of the familial patterning of these traits provided indirect evidence of population differences in genes influencing them. The Tibetan and Andean patterns of oxygen transport appear equally effective functionally as evaluated by birthweight and maximal aerobic capacity across a range of altitudes.
Authors:
C M Beall
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Publication Detail:
Type:  Comparative Study; Journal Article    
Journal Detail:
Title:  Advances in experimental medicine and biology     Volume:  475     ISSN:  0065-2598     ISO Abbreviation:  Adv. Exp. Med. Biol.     Publication Date:  2000  
Date Detail:
Created Date:  2000-10-03     Completed Date:  2000-10-03     Revised Date:  2006-11-15    
Medline Journal Info:
Nlm Unique ID:  0121103     Medline TA:  Adv Exp Med Biol     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  63-74     Citation Subset:  IM    
Affiliation:
Department of Anthropology, Case Western Reserve University, Cleveland, OH 44106-7125, USA.
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MeSH Terms
Descriptor/Qualifier:
Acclimatization / physiology*
Adolescent
Adult
Aged
Altitude*
Anoxia / complications,  physiopathology*
Birth Weight
Female
Hemoglobins / metabolism
Humans
Infant, Newborn
Male
Middle Aged
Oxygen / blood
Pregnancy
Pregnancy Complications / physiopathology
Respiration
South America
Tibet
Chemical
Reg. No./Substance:
0/Hemoglobins; 7782-44-7/Oxygen

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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