Document Detail

Tiapamil, a new calcium channel blocking agent for the treatment of effort induced chronic stable angina pectoris.
MedLine Citation:
PMID:  3743614     Owner:  NLM     Status:  MEDLINE    
The anti-anginal efficacy of tiapamil, a new calcium channel blocking agent was studied in 24 patients with established effort induced chronic stable angina pectoris. The patients were allocated randomly in a double-blind fashion to tiapamil 300 mg thrice daily or placebo for 2 weeks and thereafter all the patients received tiapamil 300 mg thrice daily in a single-blind fashion for a further 2 weeks. All patients performed symptom limited multistage graded exercise testing with computer-assisted analysis of the electrocardiogram before entering the study and at the end of the double-blind and single-blind phases. The mean exercise time to develop angina during the control test in the group which received placebo during the double-blind phase was 7.1 min; this increased to 8.5 min after 2 weeks of placebo and 9.7 min after 2 weeks of subsequent tiapamil therapy. Similarly in the group which received tiapamil during the double-blind phase the mean exercise time on control test was 6.4 min, increasing to 9.7 min and 9.7 min after 2 and 4 weeks of tiapamil therapy respectively. There were no statistical significant differences between the changes from control, seen with tiapamil and placebo during the double-blind phase. However, the changes observed between control and active therapy in the tiapamil group did reach statistical significance (p = 0.003). Similarly, 1 mm ST-segment depression time was prolonged by tiapamil therapy. The heart rate at rest and maximal exercise remained unaltered with tiapamil therapy.(ABSTRACT TRUNCATED AT 250 WORDS)
N S Khurmi; C W Robinson; M J O'Hara; E B Raftery
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Publication Detail:
Type:  Clinical Trial; Journal Article; Randomized Controlled Trial    
Journal Detail:
Title:  European journal of clinical pharmacology     Volume:  30     ISSN:  0031-6970     ISO Abbreviation:  Eur. J. Clin. Pharmacol.     Publication Date:  1986  
Date Detail:
Created Date:  1986-10-08     Completed Date:  1986-10-08     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  1256165     Medline TA:  Eur J Clin Pharmacol     Country:  GERMANY, WEST    
Other Details:
Languages:  eng     Pagination:  387-92     Citation Subset:  IM    
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MeSH Terms
Angina Pectoris / drug therapy*
Calcium Channel Blockers / adverse effects,  therapeutic use*
Chronic Disease
Double-Blind Method
Exercise Test
Hemodynamics / drug effects
Middle Aged
Propylamines / adverse effects,  therapeutic use*
Random Allocation
Reg. No./Substance:
0/Calcium Channel Blockers; 0/Propylamines; 57010-31-8/dimeditiapramine

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