Document Detail


Tiapamil--a new calcium antagonist.
MedLine Citation:
PMID:  3890216     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Calcium antagonists are an important new modality in cardiovascular therapy. Tiapamil, a congener of verapamil, is undergoing clinical and laboratory evaluation. We have undertaken experimental studies on the anti-arrhythmic properties of tiapamil, and on the intravenous use of this agent in patients with acute myocardial infarction. Reasons are given for suggesting that tiapamil warrants further clinical evaluation, after which it may join the more established calcium antagonists as a valuable therapeutic agent.
Authors:
L H Opie; C A Muller; F T Thandroyen; E A Lloyd; T Mabin; P J Commerford; H G Eichler
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't; Review    
Journal Detail:
Title:  South African medical journal = Suid-Afrikaanse tydskrif vir geneeskunde     Volume:  67     ISSN:  0256-9574     ISO Abbreviation:  S. Afr. Med. J.     Publication Date:  1985 Jun 
Date Detail:
Created Date:  1985-07-08     Completed Date:  1985-07-08     Revised Date:  2014-09-12    
Medline Journal Info:
Nlm Unique ID:  0404520     Medline TA:  S Afr Med J     Country:  SOUTH AFRICA    
Other Details:
Languages:  eng     Pagination:  881-3     Citation Subset:  IM    
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MeSH Terms
Descriptor/Qualifier:
Acute Disease
Animals
Anti-Arrhythmia Agents / therapeutic use
Arrhythmias, Cardiac / drug therapy
Calcium Channel Blockers / pharmacology*,  therapeutic use
Chemical Phenomena
Chemistry
Clinical Trials as Topic
Dogs
Double-Blind Method
Hemodynamics / drug effects
Humans
Kinetics
Myocardial Infarction / drug therapy
Propylamines / pharmacology*,  therapeutic use
Random Allocation
Rats
Swine
Tiapamil Hydrochloride
Chemical
Reg. No./Substance:
0/Anti-Arrhythmia Agents; 0/Calcium Channel Blockers; 0/Propylamines; V824N2T753/Tiapamil Hydrochloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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