Document Detail


Tiagabine: a novel drug with a GABAergic mechanism of action.
MedLine Citation:
PMID:  8039478     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
The various possibilities for manipulating the gamma-aminobutyric acid (GABA) system to augment GABAergic inhibition have been surveyed with reference to the relevant antiepileptic compounds that have been successfully or unsuccessfully investigated in relation to these different mechanisms of action. The first clinical studies of tiagabine (TGB), a novel GABA-uptake inhibitor are now available. These studies utilized a novel design, the enrichment (Amery) design, which is put into perspective compared to classical clinical trial designs. Possible advantages and disadvantages of TGB, as seen at this stage in development, have been identified.
Authors:
L Gram
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Epilepsia     Volume:  35 Suppl 5     ISSN:  0013-9580     ISO Abbreviation:  Epilepsia     Publication Date:  1994  
Date Detail:
Created Date:  1994-08-25     Completed Date:  1994-08-25     Revised Date:  2007-11-15    
Medline Journal Info:
Nlm Unique ID:  2983306R     Medline TA:  Epilepsia     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  S85-7     Citation Subset:  IM    
Affiliation:
University Clinic of Neurology, Hvidovre Hospital, Denmark.
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MeSH Terms
Descriptor/Qualifier:
Animals
Anticonvulsants / pharmacology*,  therapeutic use
Drug Design
Drugs, Investigational / pharmacology,  therapeutic use
Epilepsy / drug therapy,  physiopathology
GABA Antagonists
Humans
Nipecotic Acids / pharmacology*,  therapeutic use
Prodrugs
Randomized Controlled Trials as Topic
Research Design
Synaptic Transmission / drug effects
gamma-Aminobutyric Acid / physiology
Chemical
Reg. No./Substance:
0/Anticonvulsants; 0/Drugs, Investigational; 0/GABA Antagonists; 0/Nipecotic Acids; 0/Prodrugs; 115103-54-3/tiagabine; 56-12-2/gamma-Aminobutyric Acid

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