Document Detail

TiO2 nanotubes as a therapeutic agent for cancer thermotherapy.
MedLine Citation:
PMID:  20408983     Owner:  NLM     Status:  MEDLINE    
We report the photothermal properties as well as the in vitro cell test results of titanium oxide nanotubes (TiO(2) NTs) as a potential therapeutic agent for cancer thermotherapy in combination with near-infrared (NIR) light. TiO(2) NTs are found to have a higher photothermal effect upon exposure to NIR laser than Au nanoparticles and single-wall carbon nanotubes, which have also attracted considerable interest as therapeutic agents for cancer thermotherapy. The temperature increase of a TiO(2) NT/NaCl suspension during NIR laser exposure is larger than that of a TiO(2) NT/D.I. water suspension due to the heat generated by the formation of Na(2)TiF(6). According to the in vitro cell test results the cells exposed to NIR laser without TiO(2) NT treatment have a cell viability of 96.4%. Likewise, the cells treated with TiO(2) NTs but not with NIR irradiation also have a cell viability of 98.2%. Combination of these two techniques, however, shows a cell viability of 1.35%. Also, the cell deaths are mostly due to necrosis but partly due to late apoptosis. These results suggest that TiO(2) NTs can be used effectively as therapeutic agents for cancer thermotherapy due to their excellent photothermal properties and high biocompatibility.
Chongmu Lee; Chanseok Hong; Hohyeong Kim; Jungwoo Kang; Hong Mei Zheng
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't     Date:  2010-04-16
Journal Detail:
Title:  Photochemistry and photobiology     Volume:  86     ISSN:  1751-1097     ISO Abbreviation:  Photochem. Photobiol.     Publication Date:    2010 Jul-Aug
Date Detail:
Created Date:  2010-07-26     Completed Date:  2011-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  0376425     Medline TA:  Photochem Photobiol     Country:  United States    
Other Details:
Languages:  eng     Pagination:  981-9     Citation Subset:  IM    
Department of Materials Science and Engineering, Inha University, Incheon, Korea.
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MeSH Terms
Cell Death / drug effects
Cell Survival / drug effects
Colonic Neoplasms / therapy*
Combined Modality Therapy
Dose-Response Relationship, Drug
Hyperthermia, Induced / instrumentation,  methods*
Nanotubes / chemistry*
Particle Size
Polyethylene Glycols / chemistry,  pharmacology
Sodium Chloride / chemistry,  pharmacology
Suspensions / chemistry,  pharmacology,  therapeutic use
Titanium / chemistry,  pharmacology,  therapeutic use*
Tumor Cells, Cultured
Water / chemistry
Reg. No./Substance:
0/Polyethylene Glycols; 0/Suspensions; 13463-67-7/titanium dioxide; 7440-32-6/Titanium; 7647-14-5/Sodium Chloride; 7732-18-5/Water

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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