Document Detail


Thyroxine regulation of monolysocardiolipin acyltransferase activity in rat heart.
MedLine Citation:
PMID:  10677359     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
Treatment of rats with thyroxine has been shown to elevate the biosynthesis and content of cardiolipin in the heart [Cao, Cheng, Angel and Hatch (1995) Biochim. Biophys. Acta 1256, 241-244]. Treatment with thyroxine resulted in a 1.8-fold increase (P<0.025) in [1-(14)C]linoleate and a 1.7-fold increase (P<0.025) in [1-(14)C]oleate incorporated into cardiolipin in perfused hearts, compared with controls. The mechanism for the elevation in incorporation of unsaturated fatty acids into cardiolipin was a 1. 6-fold (P<0.025) increase in mitochondrial monolysocardiolipin acyltransferase activity. The results demonstrate that the acylation of cardiac monolysocardiolipin is regulated by thyroid hormone. Thus an elevation in cardiolipin biosynthesis is accompanied by an elevation in monolysocardiolipin acyltransferase activity to maintain the appropriate molecular species composition of cardiolipin in the cardiac mitochondrial membrane. We postulate that monolysocardiolipin acyltransferase might be a rate-limiting enzyme for the molecular remodelling of cardiolipin in the heart.
Authors:
T Mutter; V W Dolinsky; B J Ma; W A Taylor; G M Hatch
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Publication Detail:
Type:  Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  The Biochemical journal     Volume:  346 Pt 2     ISSN:  0264-6021     ISO Abbreviation:  Biochem. J.     Publication Date:  2000 Mar 
Date Detail:
Created Date:  2000-04-25     Completed Date:  2000-04-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  2984726R     Medline TA:  Biochem J     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  403-6     Citation Subset:  IM    
Affiliation:
Department of Pharmacology and Therapeutics, University of Manitoba, A307 Chown Building, 753 McDermot Avenue, Winnipeg, Manitoba, Canada R3E OW3.
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MeSH Terms
Descriptor/Qualifier:
Acyltransferases / metabolism*
Animals
Cardiolipins / metabolism*
Male
Myocardium / metabolism*
Rats
Rats, Sprague-Dawley
Thyroxine / pharmacology*
Chemical
Reg. No./Substance:
0/Cardiolipins; 7488-70-2/Thyroxine; EC 2.3.-/Acyltransferases; EC 2.3.1.-/monolysocardiolipin acyltransferase
Comments/Corrections

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