Document Detail

Thyroxine and fetal blood coagulation: a fetal lamb study.
MedLine Citation:
PMID:  8409274     Owner:  NLM     Status:  MEDLINE    
Glucocorticoids have been shown to accelerate the development of blood coagulation in the fetal lamb (Kisker, Robillard & Bohlken, 1983). The current studies examine the influence of high levels of triiodothyronine (T3) on the development of blood coagulation in the fetal lamb. Eight twin fetal lambs were studied during the last trimester of pregnancy (109-138 days gestation) using chronically placed arterial and venous catheters for infusion of T3 and withdrawal of blood samples. One fetus of each twin was infused intravenously with T3 at a constant rate of 0.6 micrograms T3/0.4 ml/h for 48 h. The other twin was infused with 5% dextrose at 0.4 ml/h for 48 h. Blood samples for measuring PT, PTT, TT, fibrinogen, factors II, V, VII, VIII, IX, X, XI and XII were obtained prior to and at the completion of the infusions. The results were analyzed for differences between the samples from paired control and T3 treated animals. Factor V significantly decreased in the T3 infused animals from 51.2% +/- 12.5% to 44.8% +/- 13.8% (P = 0.038). Factor VII also decreased in the treated animals 57.8% +/- 20% to 43.6% +/- 10.8%, but the changes were not statistically significant (P = 0.06). Factor XII significantly increased in the treated animals from 37% +/- 10.5% to 45% +/- 13.7% (P = 0.004). High levels of T3 in third trimester fetal lambs are accompanied by a moderate decrease in factor V and an increase in factor XII activity.
C T Kisker; D Bohlken; W R Clarke
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Journal of developmental physiology     Volume:  19     ISSN:  0141-9846     ISO Abbreviation:  J. Dev. Physiol.     Publication Date:  1993 Feb 
Date Detail:
Created Date:  1993-11-23     Completed Date:  1993-11-23     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7910737     Medline TA:  J Dev Physiol     Country:  ENGLAND    
Other Details:
Languages:  eng     Pagination:  57-9     Citation Subset:  IM    
Department of Pediatrics, University of Iowa College of Medicine, Iowa City 52242.
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MeSH Terms
Blood Coagulation / physiology*
Factor V / analysis
Factor XII / analysis
Fetal Blood*
Gestational Age
Hemoglobins / analysis
Litter Size
Sheep / embryology
Triiodothyronine / blood*,  pharmacology
Grant Support
Reg. No./Substance:
0/Hemoglobins; 6893-02-3/Triiodothyronine; 9001-24-5/Factor V; 9001-30-3/Factor XII

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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