Document Detail

Thyroxine Levels During Pregnancy in Healthy Women and Early Child Neurodevelopment.
MedLine Citation:
PMID:  23232616     Owner:  NLM     Status:  Publisher    
BACKGROUND:: The fetus depends on maternal thyroid hormones during pregnancy for normal brain development. Little is known about the effects of subclinical hypothyroidism and mild hypothyroxinemia during pregnancy on neurodevelopment of the child. METHODS:: We evaluated a population-based birth cohort in Spain. A total of 1761 children and their mothers were included in the main analyses. Serum levels of free thyroxine and thyrotropin were measured in pregnant women. Mental and psychomotor development of their children was assessed using the Bayley Scales of Infant Development during the second year of life. RESULTS:: Low free thyroxine levels (<5th percentile) and self-reported prepregnancy thyroid disorder without medical treatment were associated with a decrease of mental scores (Beta = -3.4 [95% confidence interval= -6.7 to -0.2]) and -5.5 [-8.9 to -2.0], respectively). No association between thyrotropin levels and mental scores or psychomotor scores was observed. CONCLUSIONS:: Low free thyroxine levels in healthy pregnant women are related to a moderate delay in child neurodevelopment. The impairment is similar in magnitude to that observed in mothers with untreated prepregnancy thyroid disorder. The value of screening pregnant women for thyroid function requires further assessment, particularly in mildly iodine-deficient areas.
Jordi Julvez; Mar Alvarez-Pedrerol; Marisa Rebagliato; Mario Murcia; Joan Forns; Raquel Garcia-Esteban; Nerea Lertxundi; Mercedes Espada; Adonina Tardón; Isolina Riaño Galán; Jordi Sunyer
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Publication Detail:
Journal Detail:
Title:  Epidemiology (Cambridge, Mass.)     Volume:  24     ISSN:  1531-5487     ISO Abbreviation:  Epidemiology     Publication Date:  2013 Jan 
Date Detail:
Created Date:  2012-12-12     Completed Date:  -     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9009644     Medline TA:  Epidemiology     Country:  -    
Other Details:
Languages:  ENG     Pagination:  150-157     Citation Subset:  -    
From the aCentre for Research in Environmental Epidemiology, Barcelona, Spain; bHospital del Mar Research Institute, Barcelona, Spain; cCIBER Epidemiologia y Salud Pública, Barcelona, Spain; dHarvard School of Public Health, Environmental Health, Boston, MA; ePublic Health Board, Conselleria de Sanitat, Valencia, Spain; fUnit of Environment and Health, Centre for Public Health Research, Valencia, Spain; gInstituto de Investigación Sanitaria de Euskadi, Donostia-San Sebastian, Spain; hFaculty of Psychology, Basque Country University (UPV-EHU), Spain; iLaboratorio Normativo de Salud Pública, Departamento de Sanidad Gobierno Vasco, Bilbao, Spain; jUniversidad de Oviedo, Area de Medicina Preventiva y Salud Pública, Oviedo, Spain; kServicio de Pediatría, Hospital San Agustín (Aviles-Asturias), Spain; lPompeu Fabra University, Barcelona, Spain.
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