| Thyrotropin secretion by thyrotropinomas is characterized by increased pulse frequency, delayed diurnal rhythm, enhanced basal secretion, spikiness, and disorderliness. | |
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MedLine Citation:
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PMID: 18682501 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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CONTEXT: Hormone secretion by somatotropinomas, corticotropinomas, and prolactinomas exhibits increased pulsatility and basal secretion, accompanied by greater disorderliness. OBJECTIVE: Our objective was to evaluate TSH secretion by thyrotropinomas with up-to-date analytical and mathematical tools. DESIGN: Twenty-four hour blood samplings at 10-min intervals in a clinical research laboratory in five patients with a thyrotropinoma and 10 healthy age- and gender-matched controls were performed. The obtained serum TSH profiles were analyzed with a new deconvolution method, approximate entropy, Cosinor analysis, and by quantification of spikiness. Results: TSH burst frequency and basal secretion were increased in patients compared with controls. TSH secretion patterns in patients were more irregular than in controls, but the diurnal rhythm was preserved at a higher mean in all patients, although with a 2-h phase delay. CONCLUSION: TSH secretion by thyrotropinomas shares many characteristics with other pituitary hormone-secreting adenomas. |
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Authors:
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Ferdinand Roelfsema; Alberto M Pereira; Daniel M Keenan; Johannes D Veldhuis; Johannes A Romijn |
Publication Detail:
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Type: Journal Article Date: 2008-08-05 |
Journal Detail:
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Title: The Journal of clinical endocrinology and metabolism Volume: 93 ISSN: 0021-972X ISO Abbreviation: J. Clin. Endocrinol. Metab. Publication Date: 2008 Oct |
Date Detail:
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Created Date: 2008-10-09 Completed Date: 2008-11-24 Revised Date: - |
Medline Journal Info:
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Nlm Unique ID: 0375362 Medline TA: J Clin Endocrinol Metab Country: United States |
Other Details:
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Languages: eng Pagination: 4052-7 Citation Subset: AIM; IM |
Affiliation:
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Department of Endocrinology and Metabolism, Leiden University Medical Center, Albinusdreef 2, NL2333ZA Leiden, The Netherlands. f.roelfsema@lumc.nl |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
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pathology,
physiopathology*,
secretion* Adult Aged Case-Control Studies Circadian Rhythm / physiology* Female Humans Male Middle Aged Models, Theoretical Pituitary Neoplasms / pathology, physiopathology*, secretion* Pulsatile Flow / physiology* Thyrotrophs / pathology, secretion Thyrotropin / blood, secretion* |
| Chemical | |
Reg. No./Substance:
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9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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