Document Detail


Thyrotropin secretion by thyrotropinomas is characterized by increased pulse frequency, delayed diurnal rhythm, enhanced basal secretion, spikiness, and disorderliness.
MedLine Citation:
PMID:  18682501     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
CONTEXT: Hormone secretion by somatotropinomas, corticotropinomas, and prolactinomas exhibits increased pulsatility and basal secretion, accompanied by greater disorderliness.
OBJECTIVE: Our objective was to evaluate TSH secretion by thyrotropinomas with up-to-date analytical and mathematical tools.
DESIGN: Twenty-four hour blood samplings at 10-min intervals in a clinical research laboratory in five patients with a thyrotropinoma and 10 healthy age- and gender-matched controls were performed. The obtained serum TSH profiles were analyzed with a new deconvolution method, approximate entropy, Cosinor analysis, and by quantification of spikiness.
RESULTS: TSH burst frequency and basal secretion were increased in patients compared with controls. TSH secretion patterns in patients were more irregular than in controls, but the diurnal rhythm was preserved at a higher mean in all patients, although with a 2-h phase delay.
CONCLUSION: TSH secretion by thyrotropinomas shares many characteristics with other pituitary hormone-secreting adenomas.
Authors:
Ferdinand Roelfsema; Alberto M Pereira; Daniel M Keenan; Johannes D Veldhuis; Johannes A Romijn
Publication Detail:
Type:  Journal Article     Date:  2008-08-05
Journal Detail:
Title:  The Journal of clinical endocrinology and metabolism     Volume:  93     ISSN:  0021-972X     ISO Abbreviation:  J. Clin. Endocrinol. Metab.     Publication Date:  2008 Oct 
Date Detail:
Created Date:  2008-10-09     Completed Date:  2008-11-24     Revised Date:  2014-07-30    
Medline Journal Info:
Nlm Unique ID:  0375362     Medline TA:  J Clin Endocrinol Metab     Country:  United States    
Other Details:
Languages:  eng     Pagination:  4052-7     Citation Subset:  AIM; IM    
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MeSH Terms
Descriptor/Qualifier:
Adenoma / pathology,  physiopathology*,  secretion*
Adult
Aged
Case-Control Studies
Circadian Rhythm / physiology*
Female
Humans
Male
Middle Aged
Models, Theoretical
Pituitary Neoplasms / pathology,  physiopathology*,  secretion*
Pulsatile Flow / physiology*
Thyrotrophs / pathology,  secretion
Thyrotropin / blood,  secretion*
Chemical
Reg. No./Substance:
9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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