| Thyrotropin-secreting pituitary adenomas. | |
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MedLine Citation:
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PMID: 8769389 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Normal or elevated thyrotropin (TSH) levels in hyperthyroid patients are characteristic of rare TSH-secreting pituitary adenoma (TSH-oma), which is easily detectable by computed tomographic (CT) scan or magnetic resonance imaging (MRI). Other diagnostic aids are an absent/impaired TSH response to thyrotropin-releasing hormone (TRH), discrepant TSH and alpha-subunit responses to TRH, high sex hormone-binding globulin (SHBG) levels, high alpha-subunit levels, and a high alpha-subunit/TSH molar ratio. Familial studies help rule out thyroid hormone resistance (RTH). Surgical removal of TSH-oma leads to clinical and biochemical remission in most patients. In surgical failures, radiotherapy and octreotide treatment have a high success rate. Undetectable TSH 1 week postsurgery suggests a definitive cure, backed up by tests for cosecreted hormones from the adenoma and dynamic tests of TSH suppression. |
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Authors:
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P Beck-Peccoz; L Persani; S Mantovani; D Cortelazzi; C Asteria |
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Publication Detail:
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Type: Journal Article; Review |
Journal Detail:
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Title: Metabolism: clinical and experimental Volume: 45 ISSN: 0026-0495 ISO Abbreviation: Metab. Clin. Exp. Publication Date: 1996 Aug |
Date Detail:
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Created Date: 1996-12-10 Completed Date: 1996-12-10 Revised Date: 2005-11-16 |
Medline Journal Info:
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Nlm Unique ID: 0375267 Medline TA: Metabolism Country: UNITED STATES |
Other Details:
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Languages: eng Pagination: 75-9 Citation Subset: IM |
Affiliation:
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Institute of Endocrine Sciences, University of Milan, Ospedale Maggiore IRCCS, Italy. |
Export Citation:
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| MeSH Terms | |
Descriptor/Qualifier:
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Adenoma
/
diagnosis,
secretion*,
therapy Diagnosis, Differential Humans Pituitary Neoplasms / diagnosis, secretion*, therapy Thyrotropin / secretion* |
| Chemical | |
Reg. No./Substance:
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9002-71-5/Thyrotropin |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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