Document Detail

Thyrotropin-releasing hormone-like material in the rat retina: changes due to environmental lighting.
MedLine Citation:
PMID:  20629     Owner:  NLM     Status:  MEDLINE    
Material reacting with an antibody to thyrotropin-releasing hormone (TRH) has been found to be present in the rat retina. The compound present in the retina cochromatographed with authentic TRH and most of its activity was lost when incubated with pyroglutamate aminopeptidase (L-pyroglutamyl-peptide hydrolase, EC, an enzyme that degrades TRH. The TRH-like activity in the rat retina was low during the night and high during the day. There was a 4-hr lag period after the lights were turned on before peak TRH levels were attained. A decrease in TRH was seen after 2 hr of darkness and the level of TRH was lowest after 4 hr of darkness. Retinal TRH is elevated by environmental lighting regardless of the time of the day. These findings suggest that TRH may be involved in retinal photorecptive mechanisms.
J M Schaeffer; M J Brownstein; J Axelrod
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Proceedings of the National Academy of Sciences of the United States of America     Volume:  74     ISSN:  0027-8424     ISO Abbreviation:  Proc. Natl. Acad. Sci. U.S.A.     Publication Date:  1977 Aug 
Date Detail:
Created Date:  1977-11-25     Completed Date:  1977-11-25     Revised Date:  2009-11-18    
Medline Journal Info:
Nlm Unique ID:  7505876     Medline TA:  Proc Natl Acad Sci U S A     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  3579-81     Citation Subset:  IM    
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MeSH Terms
Circadian Rhythm
Peptide Hydrolases / blood
Pyroglutamyl-Peptidase I
Retina / physiology*
Thyrotropin-Releasing Hormone* / isolation & purification,  physiology
Reg. No./Substance:
24305-27-9/Thyrotropin-Releasing Hormone; EC 3.4.-/Peptide Hydrolases; EC I

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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