Document Detail

Thyrotropin-releasing hormone levels decrease in hypothalamus of aging rats.
MedLine Citation:
PMID:  6151124     Owner:  NLM     Status:  MEDLINE    
Because hypothalamic and extrahypothalamic levels of thyrotropin-releasing hormone immunoreactivity (TRH-IR) undergo profound changes during the prenatal and early postnatal period in rats, similar effects with advanced aging were anticipated. For this reason we measured hypothalamic and reproductive tissue levels of TRH-IR, hypothalamic levels of somatostatin (SRIF), and beta-endorphin (EP), serum levels of prolactin (Prl), growth hormone (GH), thyrotropin (TSH), and thyroxine (T4) in young, sexually mature and 24-28 month-old male Long-Evans and Sprague-Dawley rats. Hypothalamic and prostatic levels of TRH-IR were consistently reduced as were the levels of T4 in old rats compared to young controls. Aging did not change the ratio of TRH to the major TRH-like peptide in prostates, as determined by high pressure liquid chromatography (HPLC) or the levels of hypothalamic SRIF and EP. All of the hypothalamic TRH-IR in both old and young male rats consisted of TRH by HPLC. Falling hypothalamic TRH levels and TRH secretory capacity may play a role in the blunted TSH response to cold stress in old rats.
A E Pekary; H E Carlson; T Yamada; B Sharp; P G Walfish; J M Hershman
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Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't; Research Support, U.S. Gov't, Non-P.H.S.; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neurobiology of aging     Volume:  5     ISSN:  0197-4580     ISO Abbreviation:  Neurobiol. Aging     Publication Date:  1984  
Date Detail:
Created Date:  1985-02-21     Completed Date:  1985-02-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  8100437     Medline TA:  Neurobiol Aging     Country:  UNITED STATES    
Other Details:
Languages:  eng     Pagination:  221-6     Citation Subset:  IM    
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MeSH Terms
Cerebral Cortex / analysis
Endorphins / analysis
Growth Hormone / blood
Hypothalamus / analysis*
Prolactin / blood
Prostate / analysis
Somatostatin / analysis
Thyrotropin / blood
Thyrotropin-Releasing Hormone / analysis*
Thyroxine / blood
Grant Support
Reg. No./Substance:
0/Endorphins; 24305-27-9/Thyrotropin-Releasing Hormone; 51110-01-1/Somatostatin; 60617-12-1/beta-Endorphin; 7488-70-2/Thyroxine; 9002-62-4/Prolactin; 9002-71-5/Thyrotropin; 9002-72-6/Growth Hormone

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