Document Detail

Thyrotropin releasing hormone (TRH) modified excitability of spinal cord dorsal horn cells.
MedLine Citation:
PMID:  2903474     Owner:  NLM     Status:  MEDLINE    
Thyrotropin releasing hormone (TRH) has been identified recently in fibers and cell bodies in the dorsal horn of the spinal cord, but its function in the dorsal horn is not known. The present study investigated the effects of TRH applied by iontophoresis on the excitability of dorsal horn cells that were responsive to mechanical stimulation of the ipsilateral hindlimb. TRH facilitated glutamate-induced firing of these cells without directly driving the cells in the absence of glutamate. These results suggest that TRH may modulate transmission of somatosensory information in the spinal cord.
D A Jackson; S R White
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Publication Detail:
Type:  Journal Article; Research Support, U.S. Gov't, P.H.S.    
Journal Detail:
Title:  Neuroscience letters     Volume:  92     ISSN:  0304-3940     ISO Abbreviation:  Neurosci. Lett.     Publication Date:  1988 Oct 
Date Detail:
Created Date:  1988-12-21     Completed Date:  1988-12-21     Revised Date:  2007-11-14    
Medline Journal Info:
Nlm Unique ID:  7600130     Medline TA:  Neurosci Lett     Country:  NETHERLANDS    
Other Details:
Languages:  eng     Pagination:  171-6     Citation Subset:  IM    
Department of Veterinary and Comparative Anatomy, Washington State University, Pullman 99164.
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MeSH Terms
Action Potentials / drug effects
Glutamates / pharmacology
Glutamic Acid
Hindlimb / innervation
Neurons, Afferent / drug effects,  physiology*
Physical Stimulation
Rats, Inbred Strains
Serotonin / pharmacology
Spinal Cord / drug effects,  physiology*
Thyrotropin-Releasing Hormone / pharmacology*
Grant Support
Reg. No./Substance:
0/Glutamates; 24305-27-9/Thyrotropin-Releasing Hormone; 50-67-9/Serotonin; 56-86-0/Glutamic Acid

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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