| Thyrotropin releasing hormone (TRH) modified excitability of spinal cord dorsal horn cells. | |
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MedLine Citation:
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PMID: 2903474 Owner: NLM Status: MEDLINE |
Abstract/OtherAbstract:
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Thyrotropin releasing hormone (TRH) has been identified recently in fibers and cell bodies in the dorsal horn of the spinal cord, but its function in the dorsal horn is not known. The present study investigated the effects of TRH applied by iontophoresis on the excitability of dorsal horn cells that were responsive to mechanical stimulation of the ipsilateral hindlimb. TRH facilitated glutamate-induced firing of these cells without directly driving the cells in the absence of glutamate. These results suggest that TRH may modulate transmission of somatosensory information in the spinal cord. |
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Authors:
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D A Jackson; S R White |
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Publication Detail:
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Type: Journal Article; Research Support, U.S. Gov't, P.H.S. |
Journal Detail:
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Title: Neuroscience letters Volume: 92 ISSN: 0304-3940 ISO Abbreviation: Neurosci. Lett. Publication Date: 1988 Oct |
Date Detail:
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Created Date: 1988-12-21 Completed Date: 1988-12-21 Revised Date: 2007-11-14 |
Medline Journal Info:
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Nlm Unique ID: 7600130 Medline TA: Neurosci Lett Country: NETHERLANDS |
Other Details:
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Languages: eng Pagination: 171-6 Citation Subset: IM |
Affiliation:
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Department of Veterinary and Comparative Anatomy, Washington State University, Pullman 99164. |
Export Citation:
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APA/MLA Format Download EndNote Download BibTex |
| MeSH Terms | |
Descriptor/Qualifier:
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Action Potentials
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drug effects Animals Glutamates / pharmacology Glutamic Acid Hindlimb / innervation Male Neurons, Afferent / drug effects, physiology* Physical Stimulation Rats Rats, Inbred Strains Serotonin / pharmacology Spinal Cord / drug effects, physiology* Thyrotropin-Releasing Hormone / pharmacology* |
| Grant Support | |
ID/Acronym/Agency:
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NS24388/NS/NINDS NIH HHS |
| Chemical | |
Reg. No./Substance:
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0/Glutamates; 24305-27-9/Thyrotropin-Releasing Hormone; 50-67-9/Serotonin; 56-86-0/Glutamic Acid |
From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine
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