Document Detail


Thyrotropin-producing pituitary adenoma discovered as a pituitary incidentaloma.
MedLine Citation:
PMID:  8774963     Owner:  NLM     Status:  MEDLINE    
Abstract/OtherAbstract:
A 46-year-old woman with incidentally discovered thyrotropin (TSH)-producing pituitary adenoma showed endocrine data which was consistent with TSH-producing pituitary tumor. However, she showed only slight hyperthyroidism and the oversecretion and autonomous secretion of TSH from the tumor seemed to be limited from the results of several endocrine examinations. Immunohistochemical examination revealed that not only TSH-beta and TSH-alpha but also prolactin and growth hormone synthesizing cells were present in the tumor tissue. Pituitary-transcription activator 1 (Pit-1) immunoreactivity was also detected in the adenoma cell nuclei. It was conceivable that the presented TSH-producing adenoma clinically located close to the non-functioning adenoma and Pit-1 may have played an important role in the multidirectional differentiation or development of this tumor.
Authors:
N Yamakita; T Ikeda; T Murai; T Komaki; T Hirata; K Miura
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Internal medicine (Tokyo, Japan)     Volume:  34     ISSN:  0918-2918     ISO Abbreviation:  Intern. Med.     Publication Date:  1995 Nov 
Date Detail:
Created Date:  1996-12-04     Completed Date:  1996-12-04     Revised Date:  2004-11-17    
Medline Journal Info:
Nlm Unique ID:  9204241     Medline TA:  Intern Med     Country:  JAPAN    
Other Details:
Languages:  eng     Pagination:  1055-60     Citation Subset:  IM    
Affiliation:
Department of Internal Medicine, Matsunami General Hospital, Gifu.
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MeSH Terms
Descriptor/Qualifier:
Adenoma / metabolism*,  pathology
Female
Humans
Immunohistochemistry
Middle Aged
Pituitary Neoplasms / metabolism*,  pathology
Thyrotropin / secretion*
Chemical
Reg. No./Substance:
9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine


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