Document Detail

Thyrotropin level and thyroid volume for prediction of hypothyroidism following hemithyroidectomy in an Asian patient cohort.
MedLine Citation:
PMID:  18758850     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: As more patients undergo diagnostic thyroid surgery, the development of posthemithyroidectomy hypothyroidism is becoming a major concern. We hypothesized that the preoperative thyrotropin (thyroid-stimulating hormone, TSH) level and ultrasonographically measured thyroid volume, both commonly available in thyroid nodule patients, may predict the development of posthemithyroidectomy hypothyroidism. METHOD: Among the 132 patients who underwent hemithyroidectomy from January 2004 to January 2006, a total of 101 patients who were followed for more than a year were included in the analysis. RESULTS: Biochemical hypothyroidism developed in 37 patients (36.6%). Patients who developed postoperative hypothyroidism showed higher TSH levels (P < 0.001) and smaller remnant thyroid volumes (P = 0.014). Logistic regression analysis showed that the TSH level and remnant thyroid volume were independent predictors of posthemithyroidectomy hypothyroidism (P < 0.001 and P = 0.04, respectively). A risk scoring system using these two factors was created based on the results of logistic regression analyses. The incidences of hypothyroidism were 5.3%, 12.1%, 51.7%, and 85.0% according to the risk scores of 0, 1, 2, and 3, respectively. CONCLUSIONS: Patients with a high preoperative TSH level and small thyroid volume are at high risk of developing hypothyroidism following hemithyroidectomy. Potential risk of postoperative hypothyroidism should be discussed with these patients when thyroid surgery is being considered for a diagnostic purpose.
Hyeong-Gon Moon; Eun-Jung Jung; Soon-Tae Park; Tae Sik Jung; Chi-Young Jeong; Young-Tae Ju; Young-Joon Lee; Soon-Chan Hong; Sang-Kyung Choi; Woo-Song Ha
Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  World journal of surgery     Volume:  32     ISSN:  0364-2313     ISO Abbreviation:  World J Surg     Publication Date:  2008 Nov 
Date Detail:
Created Date:  2008-10-14     Completed Date:  2009-01-13     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  7704052     Medline TA:  World J Surg     Country:  United States    
Other Details:
Languages:  eng     Pagination:  2503-8     Citation Subset:  IM    
Department of Surgery, Gyeongsang National University Hospital, 90 Chilam-dong, Jinju, Gyeongsangnam-do, 660-702, South Korea.
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MeSH Terms
Body Surface Area
Cohort Studies
Hypothyroidism / etiology*
Middle Aged
Organ Size
Predictive Value of Tests
Retrospective Studies
Risk Factors
Thyroid Neoplasms / blood*,  pathology*,  surgery
Thyroidectomy / adverse effects*
Thyrotropin / blood*
Reg. No./Substance:

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