Document Detail

TSH and free triiodothyronine concentrations are associated with weight loss in a lifestyle intervention and weight regain afterwards in obese children.
MedLine Citation:
PMID:  23211576     Owner:  NLM     Status:  MEDLINE    
OBJECTIVE: The impact of thyroid hormones on weight loss in lifestyle interventions and on weight regain afterwards is unknown. Therefore, we studied the relationships between TSH, free triiodothyronine (fT₃), free thyroxine (fT₄), and weight status, as well as their changes during and after a lifestyle intervention in obese children.
MATERIALS AND METHODS: We evaluated the weight status as BMI-SDS in 477 obese children (mean age 10.6±2.7 years, 46% male, mean BMI 28.1±4.5  kg/m²) participating in a 1-year lifestyle intervention in a 2-year longitudinal study. Changes in BMI-SDS at 1 and 2 years were correlated with TSH, fT₃, and fT₄ concentrations at baseline and their changes during the intervention.
RESULTS: A decrease in BMI-SDS during the intervention period (-0.32±0.38; P<0.001) was significantly positively associated with baseline TSH and fT₃ in multiple linear regression analyses adjusted for age, sex, pubertal stage, and baseline BMI-SDS. An increase in BMI-SDS after the end of the intervention (+0.05±0.36; P=0.011) was significantly related to the decreases in TSH and fT₃ during the intervention in multiple linear regression analyses adjusted for change in BMI-SDS during the intervention. In contrast to children with weight maintenance, children with weight regain after the end of the intervention demonstrated a decrease in their TSH levels (-0.1±1.6 vs +0.2±1.6  mU/l; P=0.03) and fT₃ (-0.2±1.1 vs +0.3±1.6  pg/ml; P<0.001) during the intervention.
CONCLUSIONS: The decreases in TSH and fT₃ concentrations during the lifestyle intervention were associated with weight regain after the intervention. Future studies should confirm that the decreases in TSH and fT₃ levels associated with weight loss are related to the change in metabolism such as resting energy expenditure.
Barbara Wolters; Nina Lass; Thomas Reinehr
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Publication Detail:
Type:  Clinical Trial; Journal Article; Research Support, Non-U.S. Gov't     Date:  2013-02-15
Journal Detail:
Title:  European journal of endocrinology / European Federation of Endocrine Societies     Volume:  168     ISSN:  1479-683X     ISO Abbreviation:  Eur. J. Endocrinol.     Publication Date:  2013 Mar 
Date Detail:
Created Date:  2013-02-18     Completed Date:  2013-04-08     Revised Date:  2013-05-08    
Medline Journal Info:
Nlm Unique ID:  9423848     Medline TA:  Eur J Endocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  323-9     Citation Subset:  IM    
Department of Pediatric Endocrinology, Diabetes and Nutrition Medicine, Vestische Hospital for Children and Children Datteln, University of Witten/Herdecke, Dr F Steiner Street 5, D-45711 Datteln, Germany.
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MeSH Terms
Body Mass Index
Child Development*
Diet, Reducing
Follow-Up Studies
Life Style
Longitudinal Studies
Obesity / blood*,  diet therapy,  prevention & control,  therapy*
Thyrotropin / blood*
Thyroxine / blood
Triiodothyronine / blood*
Weight Gain*
Weight Loss*
Reg. No./Substance:
6893-02-3/Triiodothyronine; 7488-70-2/Thyroxine; 9002-71-5/Thyrotropin

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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