Document Detail

Thyrotrophin-releasing hormone decreases feeding and increases body temperature, activity and oxygen consumption in Siberian hamsters.
MedLine Citation:
PMID:  17355315     Owner:  NLM     Status:  MEDLINE    
Thyrotrophin-releasing hormone (TRH) is known to play an important role in the control of food intake and energy metabolism in addition to its actions on the pituitary-thyroid axis. We have previously shown that central administration of TRH decreases food intake in Siberian hamsters. This species is being increasingly used as a physiological rodent model in which to understand hypothalamic control of long-term changes in energy balance because it accumulates fat reserves in long summer photoperiods, and decreases food intake and body weight when exposed to short winter photoperiods. The objectives of our study in Siberian hamsters were: (i) to investigate whether peripheral administration of TRH would mimic the effects of central administration of TRH on food intake and whether these effects would differ dependent upon the ambient photoperiod; (ii) to determine whether TRH would have an effect on energy expenditure; and (iii) to investigate the potential sites of action of TRH. Both peripheral (5-50 mg/kg body weight; i.p.) and central (0.5 microg/ml; i.c.v.) administration of TRH decreased food intake, and increased locomotor activity, body temperature and oxygen consumption in the Siberian hamster, with a rapid onset and short duration of action. Systemic treatment with TRH was equally effective in suppressing feeding regardless of ambient photoperiod. The acute effects of TRH are likely to be centrally mediated and independent of its role in the control of the production of thyroid hormones. We conclude that TRH functions to promote a catabolic energetic state by co-ordinating acute central and chronic peripheral (thyroid-mediated) function.
S Schuhler; A Warner; N Finney; G W Bennett; F J P Ebling; J M Brameld
Related Documents :
2169965 - Effects of u50,488, a selective kappa agonist, on atypical mouse opiate systems.
17549045 - Pharmacological enhancement of the endocannabinoid system in the nucleus accumbens shel...
12782215 - The interaction of bombesin and corticotropin-releasing hormone on ingestive behavior i...
2987735 - Evidence for opiate receptor involvement in the consumption of a high palatability diet...
11140905 - Meeting requirements for vitamin a.
22850385 - The first dairy product exclusively fermented by propionibacterium freudenreichii: a ne...
Publication Detail:
Type:  Comparative Study; Journal Article; Research Support, Non-U.S. Gov't    
Journal Detail:
Title:  Journal of neuroendocrinology     Volume:  19     ISSN:  0953-8194     ISO Abbreviation:  J. Neuroendocrinol.     Publication Date:  2007 Apr 
Date Detail:
Created Date:  2007-03-14     Completed Date:  2007-05-08     Revised Date:  2014-10-28    
Medline Journal Info:
Nlm Unique ID:  8913461     Medline TA:  J Neuroendocrinol     Country:  England    
Other Details:
Languages:  eng     Pagination:  239-49     Citation Subset:  IM    
Export Citation:
APA/MLA Format     Download EndNote     Download BibTex
MeSH Terms
Adaptation, Physiological
Body Temperature Regulation / physiology*
Circadian Rhythm / physiology
Dose-Response Relationship, Drug
Energy Metabolism / physiology
Feeding Behavior / physiology*
Injections, Intravenous
Injections, Intraventricular
Motor Activity / physiology*
Oxygen Consumption / physiology*
Thyrotropin-Releasing Hormone / administration & dosage,  physiology*
Grant Support
S17106//Biotechnology and Biological Sciences Research Council
Reg. No./Substance:
5Y5F15120W/Thyrotropin-Releasing Hormone

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

Previous Document:  The use of complementary medicine and therapies by patients attending a reproductive medicine unit i...
Next Document:  The role of the vagus nerve in mediating the long-term anorectic effects of leptin.