Document Detail

Thyrotoxic periodic paralysis complicated by acute hypercapnic respiratory failure and ventricular tachycardia.
MedLine Citation:
PMID:  19014279     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Thyrotoxic hypokalemic periodic paralysis in combination with an acute episode of general flaccid paralysis and hypokalemia is common in young Asian men with hyperthyroidism. We report the very rare complications of involvement of the respiratory muscles and ventricular tachycardia in this disorder. SUMMARY: A 29-year-old man exhibited profound paralysis after prolonged fasting. Severe hypokalemia was noted (K(+): 1.4 mmol/L). Although the patient was treated with potassium chloride, he suffered from respiratory distress and chest tightness. Arterial blood gas indicated acute hypercapnic respiratory failure (pCO(2): 118.9 mmHg), and ventricular tachycardia was documented by electrocardiogram. The patient was intubated for ventilatory support and treated with intravenous potassium, after which paralysis gradually resolved. Thyroid function tests showed elevated free thyroxine and low thyroid-stimulating hormone concentrations, even though the patient did not have goiter or typical symptoms of thyrotoxicosis. CONCLUSION: Thyrotoxic periodic paralysis usually involves the proximal muscles of the limbs, but on rare occasions it can affect the respiratory muscles with the potential for severe and even fatal complications.
Chung-Ze Wu; Yao-Kuang Wu; Jiunn-Diann Lin; Shi-Wen Kuo
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Publication Detail:
Type:  Case Reports; Journal Article    
Journal Detail:
Title:  Thyroid : official journal of the American Thyroid Association     Volume:  18     ISSN:  1557-9077     ISO Abbreviation:  Thyroid     Publication Date:  2008 Dec 
Date Detail:
Created Date:  2008-12-10     Completed Date:  2009-01-21     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  9104317     Medline TA:  Thyroid     Country:  United States    
Other Details:
Languages:  eng     Pagination:  1321-4     Citation Subset:  IM    
Division of Endocrinology and Metabolism, Department of Internal Medicine, Shuang Ho Hospital, Taipei Medical University, Taipei, Taiwan, Republic of China.
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MeSH Terms
Hypercapnia / complications*
Hypokalemic Periodic Paralysis / complications*,  drug therapy
Potassium Chloride / therapeutic use
Respiratory Insufficiency / etiology*
Tachycardia, Ventricular / etiology*
Thyrotoxicosis / complications*
Reg. No./Substance:
7447-40-7/Potassium Chloride

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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