Document Detail

Thyrotoxic, hypokalaemic periodic paralysis: Polynesians, an ethnic group at risk.
MedLine Citation:
PMID:  17504277     Owner:  NLM     Status:  MEDLINE    
BACKGROUND: Thyrotoxic, hypokalaemic periodic paralysis (TPP) is a reversible cause of severe muscle weakness that occurs in a small minority of thyrotoxic patients. Most cases to date have been reported in Asian men. AIMS: To evaluate the ethnic distribution of patients with TPP. METHODS: Retrospective analysis of all patients presenting with thyrotoxicosis and hypokalaemia with paralysis to two New Zealand hospitals. RESULTS: Seventy-one per cent of the 21 patients with TPP were of Polynesian ethnicity (Maori and Pacific Islander), 24% Asian and 5% European. Based on population demographics, these figures suggest a 37-fold overrepresentation for Polynesians and 159-fold for Asians compared with New Zealand Europeans. CONCLUSION: Polynesian, in addition to Asian people, are two ethnic groups at particular risk of TPP, and this condition must be considered in the differential diagnosis for patients presenting to the emergency department with severe hypokalaemia and weakness.
M S Elston; B J Orr-Walker; A M Dissanayake; J V Conaglen
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Publication Detail:
Type:  Journal Article    
Journal Detail:
Title:  Internal medicine journal     Volume:  37     ISSN:  1445-5994     ISO Abbreviation:  Intern Med J     Publication Date:  2007 May 
Date Detail:
Created Date:  2007-05-16     Completed Date:  2007-05-24     Revised Date:  -    
Medline Journal Info:
Nlm Unique ID:  101092952     Medline TA:  Intern Med J     Country:  Australia    
Other Details:
Languages:  eng     Pagination:  303-7     Citation Subset:  IM    
Department of Endocrinology, Middlemore Hospital, Auckland, New Zealand.
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MeSH Terms
Hypokalemic Periodic Paralysis / ethnology*
Middle Aged
New Zealand
Retrospective Studies
Thyrotoxicosis / ethnology*

From MEDLINE®/PubMed®, a database of the U.S. National Library of Medicine

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